A Clinical Study Of Exploring The Effects Of Rivaroxaban’s Metabolic Enzymes And Transporter-related Gene Polymorphisms On Drug Metabolism

Objective:Rivaroxaban is excreted through the liver and kidneys through a variety of ways.This article aims to study the effects of rivaroxaban metabolic enzymes and transporterrelated gene polymorphisms on drug concentration and bleeding events.Patients and methods:This study is a retrospective study.All of the 58 patients who were treated at Beijing Hospital from October 2019 to October 2020 met the study’s admission criteria.After reaching an increase in blood drug concentration,the next time the medication was administered,such as age,height,weight,weight,liver and kidney function,and drug dose clinical data,and subsequent bleeding events occurred,and the ABCB1,ABCG2,CYP3A4/5 and CYP2J2 and other genotypes.Before and 3 hours after administration,collect blood containing rivaroxaban to detect the trough concentration and concentration of rivaroxaban.Results:A total of 58 patients were reduced in this study,including 30 males and 28 females,with an average age of 73.3±9.5 years.The genotypes measured were in accordance with the Hardy-Weinberg balance.(F=3.373,P<0.05],the correlation between PT and the peak concentration of rivaroxaban was statistically significant(F=3.252,P<0.05].In patients with ABCB1rs1128503,rs2032582,rs1045642,rs4148738,ABCG2 rs2231142,CYP3A5 rs776746 and CYP2J2 rs890293 genotypes,the correlation test between the gene polymorphisms and the plasma concentration was not statistically significant.However,the haplotype analysis of ABCB1 rs1045642,rs1128503,rs4148738,rs2032582,CYP3A4 rs35599367 and CYP3A5 rs776746 showed that the frequency of haplotype CCAGCG in the bleeding subgroup was significantly higher than that in the non-bleeding subgroup(P=0.015),and the difference was statistically significant.Conclusion:There is a correlation between eGFR and the valley concentration of rivaroxaban,and there is a correlation between PT and the peak concentration of rivaroxaban.Gene mutations of various genes have no significance on the effect of bleeding events,but the same chromosome 7 locus ABCB1 rs1045642,rs1128503,rs4148738,rs2032582,CYP3A4 rs35599367 and CYP3A5 rs776746 haplotype gene frequencies are related to bleeding.