Clinical And Pathological Characteristics Of Patients With Early Gastric Cancer With Or Without Hp Infection Were Compared

Objective:Helicobacter pylori(HP)infection is closely related to the o ccurrence of early gastric cancer,but not all patients with early gastric canc er have HP infection.The purpose of this study was to explore the clinical,endoscopic and postoperative pathological characteristics of early gastric ca ncer patients with or without HP infection and their correlation,and to anal yze the relationship between Hp infection and preoperative and postoperative pathological differences.Methods:Adopt retrospective research method,strictly follow the inclus ion and exclusion criteria,the medical records of 211 patients with early ga stric cancer confirmed by pathology were collected from January 2016 to D ecember 2018 in the Center of Digestive Endoscope,affiliated Hospital of Binzhou Medical,and all of them were treated with Early gastric cancer.A ccording to the results of endoscopic rapid urokinase test or Carbon 13 ure a breath test,they were divided into Hp positive group(n=158)and negativ e group(n=53).Chi-square test and t-test were used to analyze the clinical features(including sex,age,blood type),endoscopic features(lesion locati on,lesion color,gross morphology),postoperative pathological features(lesi on size,depth of invasion,degree of tissue differentiation,pericancerous mu cosa)and pathological types of preoperative biopsy,the differences between Hp infection group and non-infected group were compared.Secondly,accor ding to whether the pathological changes of preoperative and postoperative biopsies were consistent or not,they were divided into two groups:consiste nt group and differential group,and further analyzed whether there was any difference in the distribution of Hp infection between the two groups.Results:1.There were 211 independent lesions in 211 patients with early gastric cancer,with an average age of 62.5±9.7 years,178 males and 33 females.There were 158 cases in Hp positive group and 53 cases in negative group.2.In terms of the location of the disease,74 cases(46.8%)in the Hp positive group were located in the antral part of the stomach,which was significantly higher than that 14 cases(26.4%)in the negative group,and there was significant difference between the two groups(P<0.05).In terms of the degree of tissue differentiation,77 cases(48.7%)in the positive group were well differentiated compared with 37 cases(69.8%)in the negative group,and there was significant difference between the two groups(P<0.05).In terms of the type of pericancerous mucosa,102 cases(64.6%)in the positive group with Hp infection showed atrophic gastritis with intestinal metaplasia,while 26 cases(49.1%)in the negative group.There was significant difference between the two groups(P<0.05).There was no significant difference in sex,age,blood group,lesion color,gross shape,lesion size,depth of invasion and pathological type distribution between Hp infection group and non-infection group(P>0.05).3.There were 158 cases of preoperative biopsy pathology consistent with postoperative pathology and 53 cases of difference.There was no significant difference in the distribution of HP infection between the same group and the difference group(P>0.05).Conclusions:1.Gastric antrum is the primary site of early gastric cance r with Hp infection,and the histological differentiation is poorer than that of early gastric cancer without Hp infection.Most of the surrounding mucos a showed atrophic gastritis with intestinal metaplasia.2.Early gastric cancer without Hp infection occurs in the cardia,with weller histological differenti ation than early gastric cancer infected with Hp,and the incidence of intest inal metaplasia in pericancer mucosa is lower than that in early gastric cane er infected with Hp.3.Hp infection is not a risk factor for postoperative pa thological escalation to adenocarcinoma.