Therapeutic Effect Of Supplementing Qi And Nourishing Blood On Pulmonary Infection After Chemotherapy And Its Effect On T Lym-phocyte Subsets In Acute Leukemia

Objective:To explore the clinical efficacy of the Chinese medicine of supplementing qi and nourishing blood for pulmonary infection after chemotherapy in patients with acute leukemia by observing inflammatory indicators,immune function and quality of life,providing a evidence for the treatment of pulmonary infection after AL chemotherapy.Methods:From June 2017 to December 2019,the patients with initial acute leukemia were collected from the hematology area of the second affiliated hospital of Henan university of chinese medicine,bringing into 64 patients with pulmonary bacterial infection that caused by the consolidation chemotherapy,and were randomly divided into two groups of 32 patients each.By observing the white blood cell(WBC)count,C-reactive protein(CRP)and procalcitonin(PCT)levels on the 0th,5th,8th,and 15 th day of infection treatment and the change of peripheral blood T lymphocyte subsets,TCM syndrome points and quality of life scores on the 0th、15th day of infection treatment,recording relevant safety indicators.All statistical analysis were performed with SPSS21.0.Results:1.Compared with the control group,the disappearance rate of cough and expectoration symptoms on the 15 th day of treatment in the experimental group was significantly increased(P<0.05),and fever time was significantly reduced(P<0.05).2.There was no statistically significant difference between WBC,CRP and PCT on the 0th day of treatment between the experimental group and the control group(P>0.05).Compared with the control group,WBC in the experimental group gradually increased on the 5th,8th,and 15 th day(P<0.05),CRP gradually decreased on the 5th,8th,and 15 th day(P<0.05),and PCT on the 8th,and 15 th day gradually decreased(P<0.05).3.There was no difference in the proportion of CD3+,CD4+,CD8+ T lymphocytes and CD4+/CD8+ ratio between the experimental group and the control group on the 0th day of treatment(P>0.05).There are differences between the groups on the 15 th day and the 0th day of treatment(P<0.05),and there was a difference between the experimental group and the control group on the 15 th day of treatment(P<0.05).4.There was no difference in the scores of quality of life between the experimental group and the control group on the 0th day of treatment(P>0.05).Compared with the control group,the general health status(QL)scores and physical function(PF)scores in the functional areas of the experimental group increased on the15 th day of treatment(P<0.05).The improvement of dyspnoea(DY),fatigue(FA),appetite(AP),nausea and vomiting(NV),and constipation(CO)in the symptom field was different(P<0.05),and social function(SF),cognitive function(CF),role function(RF),emotional function(EF)in the functional field and financial difficulties(FI),pain(PA),diarrhea(DI),and insomnia(SL)in the symptom field were not significantly changed(P>0.05).5.The clinical efficacy between the experimental group and the control group:the total effective rate of the experimental group was 93.33%,the clinical recovery was 20%,the marked effect was 53.33%,the effective rate was 20%,and the invalid rate was 6.67%.The total effective rate of the control group was 70%,clinical recovery 6.67%,marked effect 30%,effective 33.33%,ineffective 30%,compared with the control group,the total effective rate of the experimental group was higher(P<0.05).There was no difference in syndrome scores between the two groups on the 0th day of treatment(P>0.05).Compared with the control group,the TCM syndrome of the experimental group improved on the 15 th day of treatment(P<0.05).6.During the observation period,there was no obvious abnormality of liver and kidney functions in the two groups.Conclusion:1.The therapy of supplementing qi and nourishing blood supplementing qi and nourishing blood can promote the recovery of pulmonary infection in patients with acute leukemia after chemotherapy,reduce the level of inflammatory factors in vivo,and control the inflammatory response.2.The therapy of supplementing qi and nourishing blood supplementing qi and nourishing blood can increase the proportion of CD3+,CD4+ T lymphocyte and the ratio of CD4+/CD8+,reduce the proportion of CD8+ T lymphocyte,enhance the immune function and anti-infection ability of patients with pulmonary infection after chemotherapy of acute leukemia.3.The therapy of supplementing qi and nourishing blood can improve the clinical symptoms and TCM syndromes of patients with pulmonary infection after chemotherapy of acute leukemia,improve the quality of life,and is safe and effective.