Clinical Observation Of Sanhan Chushi Jianxi Decoction In The Treatment Of Knee Osteoarthritis With Syndrome Of Cold-dampness Obstruction

Objective:To observe the efficacy and safety of Sanhan Chushi Jianxi Decoction in the treatment of KOA(Cold-damp Arthralgia Syndrome)patients.Methods:60 patients of Knee Osteoarthritis with Syndrome of Cold-dampness Obstruction,who admitted in Orthopaedics and Traumatology Diagnosis and Treatment Center of Henan Hospital of Troditional Chinese Medcine,from January 2019 to December 2019,were selected.All patients were randomly divided into the treatment group and the control group,30 cases in each group.The treatmennt group was treated with Sanhan Chushi Jianxi Decoction and Dexketoprofen tromethamine tablet,the control group was treated with Dexketoprofen tromethamine tablet,with a course of 2 weeks.The patients were followed-up for 4 weeks.Before treatment,after treatment and after 4-week follow-up,the total effective rate,WOMAC score of knee joint,threshold of knee joint tenderness and Chinese medical syndrome score were compared in both groups.Results:After treatment,based on the evaluation of the efficacy of the WOMAC score,the total effective rates were 93.3%in the treatment group and 66.67%in the control group,with statistically significant difference.The clinical efficacy of the treatment group was better than that of the control group(P<0.05).Based on the evaluation of the efficacy of the Chinese medical syndrome score,the total effective rates were 96.67%in the treatment group and 73.33%in the control group,with statistically significant difference.The clinical efficacy of the treatment group was better than that of the control group(P<0.05).Compare with that before treatment,the WOMAC score was decreased in the both groups after treatment.After treatment,the WOMAC score in the treatment group was lower than that in the control group(P<0.05).Compare with that after treatment,the WOMAC score was increased in the both groups after 4-week follow-up.After 4-week follow-up,the WOMAC score in the treatment group was lower than that in the control group(P<0.05).Compare with that before treatment,the Chinese medical syndrome score was decreased in the both groups after treatment.After treatment,the Chinese medical syndrome score in the treatment group was lower than that in the control group(P<0.05).Compare with that after treatment,the Chinese medical syndrome score was increased in the both groups after 4-week follow-up.After 4-week follow-up,the Chinese medical syndrome score in the treatment group was lower than that in the control group(P<0.05).Compare with that before treatment,the threshold of adductor nodules tenderness was increased in the both groups after treatment.After treatment,the threshold of adductor nodules tenderness in the treatment group was higher than that in the control group(P<0.05).Compare with that after treatment,the threshold of adductor nodules tenderness was decreased in the both groups after 4-week follow-up.After 4-week follow-up,the threshold of medial condyle tenderness in the treatment group was higher than that in the control group(P<0.05).Compare with that before treatment,the threshold of medial condyle tenderness was increased in the both groups after treatment.After treatment,the threshold of medial condyle tenderness in the treatment group was higher than that in the control group(P<0.05).Compare with that after treatment,the threshold of medial condyle tenderness was decreased in the both groups after 4-week follow-up.After 4-week follow-up,the threshold of medial condyle tenderness in the treatment group was higher than that in the control group(P<0.05).The incidence rates of adverse reactions were 3.33%in the treatment group,and 10.00%in the control group,with no statistically significant difference(P>0.05).Conlusion:Sanhan Chushi Jianxi Decoction had was effective in treating Knee Osteoarthritis with Syndrome of Cold-dampness Obstruction,which could effectively improve knee function and threshold of knee joint tenderness,which is worthy of clinical promotion and application.