Clinical Observation Of Huanglian Zicao Ointment On Wound Of Stage Ⅲ Refractory Pressure Sore

Objective:To compare the clinical efficacy and safety of Huanglian Zicao ointment combined with compound polymyxin B ointment and simple compound polymyxin B ointment in the treatment of stage III refractory pressure sore,so as to provide a new and effective treatment method for the future clinical treatment of pressure sore.Method:Sixty patients with stage III refractory pressure sore were selected and numbered according to the order of admission time,and were divided into experimental group and control group by random number table method,each group was30 cases.Both groups were given routine basic treatment,the control group: to give compound polymyxin B ointment to change medicine;experimental group: to give Coptis chinensis Zicao ointment compound polymyxin B ointment to change medicine,the treatment period is 28 days.the wound healing rate,PUSH score and VAS score of pressure sore in the two groups were recorded on the 7th,14 th,21st and 28 th days after the start of treatment.the relevant data were statistically processed and analyzed by SPSS22.0 software to evaluate the clinical efficacy of the two groups.Results:1.Comparison of baseline data: A total of 60 patients were included in this study,of which 55 successfully completed clinical observation,28 in the experimental group and 27 in the control group.differences in age,sex,and course of disease between the two groups before treatment were not statistically significant(P>0.05).2.Comparison of wound conditions: there was no significant difference in wound area size,PUSH score and VAS score between the two groups at the first evaluation of admission(P>0.05).3.Comparison of wound healing rate: there was no significant difference in wound healing rate between the two groups on day 7(P=0.425>0.05);on day 14,21 and28,the wound healing rate of the test group was higher than that of the control group,the difference was statistically significant(P<0.05),and the wound healing effect of the test group was better.Comparison of wound healing rate of continuous observation node showed that there was no significant difference in wound healing rate on the 7th day;since the 7th day,the wound healing rate of the two groups increased in varying degrees,and the test group was higher than the control group,and the difference was statistically significant(P<0.05).4.Comparison of wound PUSH scores: on the 7th,14 th,21st,28 th day,the wound PUSH score of the test group was lower than that of the control group,the difference was statistically significant(P<0.05),and the wound healing effect of the test group was better.The comparison of wound PUSH score of continuous observation node showed that with the passage of treatment time,the PUSH score decreased to different degrees,and the experimental group was superior to the control group,and the difference was statistically significant(P<0.05).5.Comparison of wound VAS scores: there was no significant difference in wound VAS score between the two groups on day 7(P=0.553>0.05);the wound VAS score of the test group on day 14,21 and 28 was lower than that of the control group,and the difference was statistically significant(P<0.05).the pain relief effect of the test group was better.the comparison of wound VAS score of continuous observation node showed that there was no significant difference in wound VAS score on the 7th day;since the 7th day,the wound VAS scores of the two groups decreased in varying degrees,and the experimental group was superior to the control group,and the difference was statistically significant(P<0.05).6.Safety evaluation: In the course of treatment,there were no adverse reactions,such as allergy and liver and kidney function damage,and other safety indexes were not abnormal.Conclusion:Huanglian Zicao ointment combined with compound polymyxin B ointment in the treatment of stage III refractory pressure sore can effectively relieve the pain symptoms and promote the wound healing of pressure sore.Its clinical effect is obviously better than that of simple compound polymyxin B ointment,and its safety is good,which is worthy of clinical promotion.