Correlation Between Ultrasound Multimode Imaging And Immunological Indexes Of Ductal Carcinoma In Situ And Invasive Ductal Carcinoma

Objective The purpose of this study is to investigate the difference of ultrasonographic features between Ductal Carcinoma in Situ(DCIS)and Invasive Ductal Carcinoma(IDC),and to analyze whether there is a correlation between ultrasonic features and immunohistochemical indicators of IDC and DCIS,and to explore whether it can be used as a predictor of breast cancer molecular classification.Methods A retrospective review was performed in 74 women with 77 lesions.All lesions were divided into DCIS(31 lesions)and IDC(46 lesions)according to postoperative pathology.The gray-scale ultrasound,color Doppler,contrast-enhanced ultrasound,and shear wave elastrography were used to measure the two-dimensional maximum diameter,shape,hyperechoic halo,posterior echo,microcalcification,blood supply,and the distribution of contrast agent,enhancement intensity,filling defect,changes in size before and after contrast enhancement,peripheral penetration vessels,enhancement order,enhancement time,clearance time,peripheral ring enhancement,and Young’s modulus value Emax were compared.The two groups of ultrasonic images were analyzed.The differences between the two indicators were analyzed,and the correlation between the two groups of ultrasonic features and immunohistochemical indicators(Ki67 index,PR,ER,HER-2)were analyzed.Results:In the two groups,the mean age of patients,hyperechoic halo,posterior echo,the changes in size before and after contrast enhancement and Emax were statistically significant between the DCIS and IDC groups(P<0.05).In the IDC group,the expression of ER,PR and the two-dimensional maximum diameter of breast lesions were statistically significant(P<0.05).There was a correlation between ER expression with the average age of patients and two-dimensional maximum diameter of breast lesions(P<0.05).There was a correlation between Ki67 expression with the two-dimensional maximum diameter of breast lesions,posterior echo,punctate calcification,and contrast enhancement order(P<0.05).There was a correlation between HER-2 expression with the two-dimensional maximum diameter of breast lesions,Emax,points and calcification and the differences were statistically significant(P < 0.05).In the DCIS group,there was no correlation between ultrasonographic features and immuohistochemical indicators.Conclusion : Under ultrasound multimodality,there are differences in some ultrasonographic features between the DCIS group and the IDC group.There is also a correlation between some of ultrasonographic features of the IDC group and immunohistochemical indicators.In the DCIS group,there was no correlation between ultrasonographic features and immuohistochemical indicators,so IDC is more invasive than DCIS.Some of the DCIS lesions were found without mass effect,so more attention should be paid.