The Study Of Professor Li Can-dong’s Experience In The Treatment Of Chronic Gastritis Based On Data Mining

Objective:Using the data mining technology to statistically analyze the information of chronic gastritis cases treated by Professor LI Can-dong,to understand the composition of patients’ basic information,and to observe the distribution pattern of symptoms,evidence elements,traditional Chinese medicine classification and properties,taste and meridian tropism.To analyze and summarize the treatment ideas and medication pattern of chronic gastritis treated by Prof.LI,which can inherit the experience of famous doctors and enrich the clinical thinking.Methods:Two hundred patients with chronic gastritis who met the inclusion criteria and were treated by Prof.LI Can-dong between 09/2017 and 01/2021 were collected,and the resulting case data were entered into Excel with basic information and medication information to form a medical case data sheet,which was pre-processed and standardized.Syndrome element with≥70 points in the cases were derived through the TCM health state identification system.Frequency statistics,cluster analysis and association rule analysis were performed on the basic patient information,symptoms,evidence elements,drug classification,drug properties and taste,and meridian tropism,etc.The academic thought and clinical experience of Professor LI Can-dong in the treatment of chronic gastritis are summarized by combining the rules of medication used by Professor LI Can-dong in the treatment of chronic gastritis.Results:1.Among the 200 cases of chronic gastritis in this study,there were 120 women(60%)and 80 men(40%).The age of the patients was predominantly 30-69 years old,accounting for a total of 85.5%.2.Symptom statistics: The main gastrointestinal symptoms of 200 patients with chronic gastritis were stomach pain,gastric swelling,belching,acid reflux and heartburn,and the main accompanying symptoms were poor sleep,thirst,bitterness,lethargy and irritability.3.Evidence statistics: Frequency analysis showed that the top three total pathological elements were stomach(70.0%),liver(49.0%),and spleen(36.5%);the top three total actual elements were qi stagnation(71.5%),heat(52.0%),and dampness(45.0%);the top three total deficiency elements were yin deficiency(49.0%),yang deficiency(40.5%),and qi deficiency(39.5%).4.Medication pattern: In the first prescription of Prof.LI Can-dong for the treatment of chronic gastritis,excluding licorice,which harmonizes all medicines,119 Chinese medicines were used,with a frequency of 1703 times,and a total of 24 medicines with a frequency greater than or equal to 20 times,accounting for 79.33% of the total,which are commonly used for the treatment of chronic gastritis.The commonly used drugs can be divided into 10 categories according to the efficacy of the drugs,which Tonic for deficiency syndromes are used most frequently,accounting for 25.98% of the high-frequency drugs;followed by drugs for regulating qi,accounting for 17.25%;again,Digestive drugs,accounting for 13.69%;and fourthly,Heat-Clearing drugs,accounting for 13.18%,which are the core drug categories for the treatment of chronic gastritis by Professor LI Can-dong.Statistics show that high-frequency drugs have the most warm(slightly warm)drugs,accounting for 47.22%;cold(slightly cold)drugs account for 25.91%;mild drugs account for 19.32%,with warm,cold and mild drugs accounting for the majority.Among the medicinal taste,pungent medicines were used most frequently,accounting for 53.37%,followed by bitter medicines,accounting for 44.41%,and sweet medicines,accounting for 39.82%.The overall use of drugs is mainly characterized by hard work to regulate the qi flow up and down of the spleen and stomach,and sweet and slow to supplement the deficiency of the spleen and stomach.The frequency of drugs attributed to the spleen,stomach,lung,liver,heart,gall bladder,large intestine,small intestine,and kidney meridians were greater than or equal to 10%.5.The main core prescription combinations are:(1)Scutellaria baicalensis,jujube,Semen,Coptis chinensis,dried ginger,Radix Codonopsis pilosulae,roasted licorice,and finger citron;(2)Atractylodes macrocephala,Saposhnikovia divaricata,Paeonia lactiflora,and Chen Pi;(3)Paeonia lactiflora,Radix bupleurum,Citrus aurantium,and Glycyrrhiza glabra;(4)Perilla stems,Chaihu,Chen Pi,Poria,Divine Comedy.6.The main pairs of medicines for the treatment of chronic gastritis are Coptis chinensis+ Evodia rutaecarpa,Rhizoma Corydalis + Szechwan Chinaberry Fruit,and Trogopterus Dung + Typhae Pollen.Conclusion:1.The main age of chronic gastritis is from 30 to 69 years old.2.The main disease sites of chronic gastritis are stomach,liver and spleen;The main solid syndromes were qi stagnation,heat and dampness.The main deficiency syndrome elements are Yin deficiency,Yang deficiency and Qi deficiency.3.Professor Li Candong believed that the disease of chronic gastritis was the original deficiency and the normal condition,and the basic pathogenesis was "liver and stomach qi stagnation and stomach disharmony".The prescription drugs were warm,cold and flat,and the taste was bitter and sweet,and Banxia Xiexin Decoction,Tongxie Yaofang,sini powder and Xiangsu powder were mostly used for treatment.For patients with blood stasis,Chinese herbal medicine such as Wulingzhi,Pu Huang,Chuan Melia Fructus,Yanhusuo and so on should be used to promote blood circulation and remove blood stasis.4.The results of data mining reflect that Professor Li Candong pays attention to the thought of "five distinctions" in the clinical treatment of chronic gastritis.In the treatment of chronic gastritis,the whole process attaches importance to maintaining healthy qi and regulating qi.