The Predictive Role Of MAPK10 In The Efficacy And Prognosis Of Neoadjuvant Chemotherapy For Squamous Cell Carcinoma Of The Cervix

BACKGROUND: Cervical cancer(CC)is recognized worldwide as a common cancer with a high risk of recurrence.Although the molecular mechanisms underlying chemotherapy resistance and recurrence of cervical cancer have been extensively studied,the key molecules have not been identified.It is important to find molecular biological markers that are predictive of neoadjuvant chemotherapy(NACT).OBJECTIVE: To discuss the relevance of MitogenActivated Protein Kinase 10(MAPK10)to the efficacy and prognosis of NACT in cervical cancer.METHODS: We used immunohistochemical assays to detect the expression of MAPK10 gene in chemotherapy-sensitive and drug-resistant groups,analyzed the relationship between the expression in different sensitive groups and the clinicopathological characteristics and survival of patients with cervical squamous cell carcinoma,and determined the predictive role of MAPK10 on the efficacy and prognosis of NACT in cervical squamous carcinoma.RESULTS: Relative to normal cervical tissues,MAPK10 expression was significantly decreased in cervical cancer tissues,and the difference was statistically significant(P<0.05).MAPK10 expression was significantly upregulated in the neoadjuvant chemotherapy-sensitive group,and the difference was statistically significant(P<0.05).In terms of clinicopathological characteristics,MAPK10 expression correlated with patients’ age,clinical stage,pathological stage,lymphatic metastasis,and There was no correlation between MAPK10 expression and patients’ age,clinical stage,pathological stage,lymphatic metastasis,and deep infiltration(P<0.05).log-rank analysis suggested that patients with cervical cancer with low MAPK10 expression might obtain shorter survival compared with those with high expression(HR=0.6,95% CI: 0.36 to 1,P=0.045).CONCLUSION: Low expression of MAPK10 in cancerous tissues of cervical cancer patients correlates with ineffective NACT and correlates with poor prognosis,which can be used as a reference indicator to predict the effect of NACT.