Analysis Between NLR And SII And Recurrence For Stage ⅡB～ⅣA Cervical Cancer

Objective: To analyze the relationships between the values(before and after radiotherapy)of NLR,SII and recurrence in patients with cervical cancer.Methods: Clinical data of 172 patients with stage Ⅱb～Ⅳa cervical cancer who received radiotherapy from December 2015 to December 2019 were retrospectively analyzed.NLR and SII values before and after radiotherapy were calculated by blood routine examination.All patients were divided into recurrence group and non-recurrence group.The differences of NLR and SII values between the two groups were compared.Results: Receiver operating characteristic curve showed that the optimal cut-off values of NLR before and after radiotherapy were 1.84 and 5.27,respectively,while that of SII were 993.29 and 1171.63,respectively.According to the cut-off values,the patients were divided into low NLR group(58 cases)before radiotherapy,high NLR group(114 cases)before radiotherapy,low NLR group(70 cases)after radiotherapy,high NLR group(102 cases)after radiotherapy,low SII group(142 cases)before radiotherapy,high SII group(30 cases)before radiotherapy,low SII group(102 cases)after radiotherapy and high SII group(70 cases)after radiotherapy.The value of NLR before radiotherapy was significantly correlated with age(P=0.024)and number of deliveries(P=0.007),but there is no significant relationships with tumor diameter,BMI,clinical stage,pathological classification,histological grade and diabetes mellitus(P>0.05).NLR after radiotherapy had no correlation with all factors(P>0.05).SII value before radiotherapy was correlated with age(P<0.001),tumor diameter(P=0.001)and clinical stage(P<0.001),but there is no significant relationships with pathological classification,histological grade,number of delivery,BMI,and diabetes mellitus(P>0.05).SII value after radiotherapy was significantly correlated with age(P=0.005),tumor diameter(P=0.011)and clinical stage(P=0.001),while there is no significant relationships with number of delivery,BMI,pathological classification and histological grade(P>0.05).NLR and SII values before and after radiotherapy(P=0.002,P<0.001,P<0.001,P=0.001),clinical stage(P=0.003),pathological classification(P<0.001)and histological grade(P=0.003)were affecting the recurrence of cervical cancer patients after radiotherapy.Logistic regression analysis showed that NLR value before radiotherapy(P=0.001),pathological classification(P=0.001)and histological grade(P=0.022)were risk factors affecting the recurrence of cervical cancer patients.The ROC curve was drawn and the area under the curve of each risk factor was compared.The area under the curve of the NLR value before radiotherapy was higher than that of histological grade and pathological classification.In predictive ability,there are no significant difference between NLR value before radiotherapy,histological grade and pathological classification.In patients with cervical squamous cell carcinoma,NLR before radiotherapy is a risk factor for recurrence(P=0.001).Conclusion: Cervical cancer patients with high NLR and SII values have high recurrence rate.High NLR value before radiotherapy is a risk factor affecting the recurrence of cervical cancer.