The Predictive Effect Of Coagulation Related Parameters In The Prognosis Of Intravenous Thrombolysis In Acute Ischemic Stroke

Objective:Acute ischemic stroke(AIS)has always endangered human physical and mental health,and it accounts for a large proportion of cerebrovascular disease(CVD),with a high prevalence rate,disability rate,and mortality rate Not down.With the deepening of disease research,although the diagnosis methods,drug development,and treatment methods have been continuously improved,the treatment results of AIS are still unsatisfactory.The current status of the treatment and the problems facing it still have many challenges.The purpose of this study was to analyze the baseline data and coagulationrelated indicators of AIS patients,and to study the effect of coagulation and fibrous volume-related parameters on the prognosis of venous thrombolysis in AIS patients.Methods:This article retrospectively analyzed the clinical data and related indexes of coagulation function of all AIS patients who received intravenous thrombolysis in our hospital from January 2010 to August2017,according to the modified Rankin scale(Modified Rankin scale,m RS)one year later.)Divided into a good prognosis group(m RS≤1)and a poor prognosis group(m RS> 1),and finally carried out multivariate analysis on independent risk factors related to prognosis.Results:There were 278 cases in the good prognosis group and 84 cases in the poor prognosis group.Multivariate logistic regression analysis data showed such biomarkers as fibrinogen degeneration products(FDP)and Thromboelastography–MA(TEG-MA)were significantly related to poor prognosis independently.FDP shows better warning value than that of TEG-MA.The cutoff number was 1.33mg/L and 65.25 mm,respectively.NIHSS score at admission and age were positively correlated with poor prognosis of intravenous thrombolysis.Conclusions:The final analysis of FDP and TEG-MA are both independent risk factors for the prognosis of AIS venous thrombolysis,and the early warning value of FDP is slightly higher than TEG-MA;the higher the FDP and TEG-MA,the worse the prognosis.The higher the NIHSS score at admission and the older the age indicate that AIS patients may have a worse prognosis.