Analysis Of Insulin Resistance And Islet Function In Non-diabetic OSAHS Patients

Aim:To study the insulin resistance and islet function in patients with non-diabetic obstructive sleep apnea hypopnea syndrome(OSAHS)of different severity,besides the evaluation value of dynamic and static indicators in them.Contents and methods: There are 101 inpatients who underwent sleep breathing monitoring in our hospital were brought into results.All subjects underwent an oral glucose tolerance test,measuring plasma glucose,insulin and C peptide load for 0min and120 min,respectively.According to the sleep apnea hypopnea index(AHI),the study subjects were divided into the control group(AHI ≤15 events / h)and the OSAHS group(AHI> 15 events / h);the latter was further divided into the mild-to-moderate OSAHS group(AHI> 15-30 events / h)and the severe OSAHS group(AHI> 30 events / h).The static insulin resistance index(HOMA-IR,IAI,QUICKI),dynamic insulin resistance index(Matsuda index,ISIstumvoll),besides,the static islet function index(HOMA-βFβCI)and dynamic islet function indexes(Stumvoll 1-phase index,ΔI / ΔG * 1 / IR)between these groups were analyzed.And we explored the relationship between AHI and hypoxic conditions(Ts90%)of OSAHS patients and the different indicators of insulin resistance and islet function.Results:(1)Comparing with the control group,the OSAHS group had a higher FβCI,the mild to moderate OSAHS group had lower QUICKI,ISIstumvoll,and Matsuda indexes;the severe OSAHS group had higher FPG,FINS,FCP,ΔI / ΔG * 1 / IR,and QUICKI,ISIstumvoll were lower.(2)when FPG,HOMA-IR,IAI,and QUICKI were adjusted,AHI is independently related to FCP,ISIstumvoll,ΔI / ΔG * 1 / IR.(3)After adjusting FPG,HOMA-IR,QUICKI,FCP,and Matsuda index,Ts90% is only negatively related to QUICKI.Conclusion: non-diabetic OSAHS patients have insulin resistance,and compensatory increase of islet secretion function,there is a tendency to increase with the severity was increased,regardless of the degree of hypoxia of OSAHS.