| Objectives:To understand the characteristics of thyroid function in patients with depression and the correlation with depression and anxiety levels;observe the efficacy of early antidepressant drugs combined with thyroxine therapy in patients with first-episode depression.Methods:1.By the method of clinical epidemiology,randomly selected from June 2020 to December 2020 in 3 armour hospital affiliated to a university during the psychosomatic medicine clinic patients and the medical examination center patients as the research object,according to the inclusion criteria and exclusion criteria,302 cases of depression group and 302 cases of healthy control group were included.The Hamilton Depression Scale-24(HAMD-24)and the Hamilton Anxiety Scale(HAMA)were used to evaluate the depression and anxiety levels of the two groups of subjects,and to detect the thyroid function index values of the two groups of subjects.Compare the difference of thyroid function and anxiety and depression degree between depression group and healthy control group,and analyze the correlation between thyroid function indexes and anxiety and depression degree in depression group.2.Among 302 patients in the depression group,64 hospitalized patients with first-onset depression were selected and divided into the experimental group and the control group with 32 patients in each group by random grouping method.The experimental group was treated with antidepressants combined with thyroxine,and the control group was treated with antidepressants alone,before and after two weeks of treatment,evaluate the anxiety and depression degree and test the thyroid function indicators of the two groups.Analyze the changes in the degree of depression and anxiety and thyroid function in the experimental group and the control group before and after two weeks of treatment,and compare the differences in curative effect between the two groups.Research results:1.The HAMD-24 and HAMD scores in the depression group were higher than those in the healthy control group and the differences were statistically significant(P<0.05);The serum T3,T4 and FT3 indicators in the depression group were lower than those in the healthy control group,and the differences were statistically significant(P<0.05);There was no significant differences in serum TSH and FT4 indexes between the two groups(P>0.05).2.In the depression group,serum T3 and T4 indexes were negatively correlated with HAMD-24 total scores and HAMA total scores;serum TSH,FT3,FT4 indexes were not significantly correlated with HAMD-24 and HAMA total scores(P>0.05).3.The total score of HAMD-24 and HAMA in the experimental group of patients were lower than before two weeks after treatment,the differences were statistically significant(P<0.05);anxiety/somatization factor,retardation factor and somatic anxiety factor scores were lower after treatment than before and the differences were statistically significant(P<0.05),there was no significant difference in other factors before and after treatment(P > 0.05).;The serum T3 and T4 index values of patients in the experimental group were higher than before treatment after two weeks of treatment and the differences were statistically significant(P<0.05),there was no significant difference in other thyroid function indexes before and after treatment(P > 0.05).The total scores of HAMD-24 and HAMA in the control group were lower than before two weeks after treatment,the difference was statistically significant(P<0.05);cognitive impairment,sleep disorder and mental anxiety factor scores were lower after treatment than before and the differences were statistically significant(P<0.05),there was no significant difference in other factors before and after treatment(P >0.05);there was no significant difference in thyroid function indexes in control group before and after treatment(P > 0.05).There was no significant difference between the experimental group and the control group in the number of effective depressive and anxiety symptoms improvement after two weeks of treatment(P>0.05).After two weeks of treatment,the increase degree of serum T3 and T4 indexes in the experimental group was significantly higher than that in the control group and the differences were statistically significant(P < 0.05).There was no significant difference in the changes of other thyroid function indexes between the two groups(P>0.05).Research conclusions:1.Patients with depression have abnormal thyroid function,in which serum T3,T4,and FT3 indicators decrease significantly;2.The serum T3 and T4 indexes of patients with depression are negatively correlated with the degree of depression and anxiety,and other thyroid function indexes have no obvious correlation with the degree of depression and anxiety;3.The combination of antidepressant drugs and thyroxine therapy in first-episode depression patients does not significantly affect the improvement of overall depression and anxiety symptoms,but it can help to improve the somatization/somatic anxiety,slow symptoms and some thyroid function. |
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