Changes Of Brain Structure And Function In Vestibular Migraine

Objective: To apply Resting state functional magnetic resonance imaging(Rs-f MRI)to explore the gray matter volume(GMV),brain function,and brain default in patients with vestibular migraine(VM).The unique change characteristics of the functional connection(FC)of the default mode network(DMN).Methods: 30 VM patients(VM group)who met the International Headache Association(3rd edition)diagnostic criteria for VM and 34 normal volunteers(control group)were enrolled in this study.All the scanning were performed on a 3T MR scanner(Magnetom Prisma,Siemens Healthineer,Erlangen,Germany)with a64-channel head-neck coil.Brain structure image was acquired using magnetization-prepared two rapid acquisition gradient echoes sequence(MP2RAGE).The Rs-f MRI sequence was preformed with simultaneous multi slice(SMS)technique for getting better SNR about raw date.Different brain regions of GMV and ALFF values were extracted and compared between two groups using Voxel-based morphology(VBM)and amplitude of low-frequency fluctuation(ALFF)method.The related functional connection analysis method of posterior cingulate cortex(PCC)seed point was used to extract the brain areas changed by DMN in the resting state.Independent sample t test was used between groups.Results: Compared with the control group,gray matter volume was decreased in bilateral talus fissure cortex,bilateral lingual gyrus,bilateral precuneus,bilateral cuneus,bilateral posterior cingulate gyrus,bilateral parahippocampal gyrus,left insula and the bean-shaped putamen about the patient group(p<0.05,Alpha Sim correction).The ALFF values about patient group were increased in bilateral precuneus,bilateral supplementary motor areas,bilateral medial and lateral cingulate gyrus,bilateral posterior cingulate gyrus,left posterior cingulate gyrus,right middle frontal gyrus,right middle temporal gyrus,right middle occipital gyrus and right superior marginal gyrus,.The ALFF values about patient group were decreased in left postcentral gyrus and left superior temporal gyrus(p<0.05,Alpha Sim correction).Compared with the control group,the brain areas in the VM group with enhanced FC between DMN and PCC were bilateral cerebellar area Ⅸ,bilateral parahippocampal gyrus,bilateral hippocampus,left fusiform gyrus.The brain areas with weakened connections are bilateral supplementary motor areas,bilateral superior marginal gyrus,bilateral superior temporal gyrus,left cerebellar area Ⅵ,right dorsolateral superior frontal gyrus,right middle frontal gyrus,right triangular inferior frontal gyrus,right insular tegmental inferior frontal gyrus,right temporal pole,right middle temporal gyrus and left parietal-inferior marginal angular gyrus(p<0.05,Alpha Sim correction).Conclusion: Compared with the control group,patients with VM had abnormal GMV and ALFF values in multiple brain areas,and had changes in the brain default network function connection in the resting state.The differences in brain structure,function and FC provide theoretical support for the timely treatment of VM in clinical practice.