Study On The Relationship Between BPV And Urinary UACR And TBIL In Patients With Essential Hypertension

Objective: Study the relationship in primary level 3 patients with Blood pressure variability(BPV)and urine trace albumin/creatinine(UACR)、serum total bilirubin(TBIL),to provide reference for prevention and early diagnosis of kidney damage,providing a new method to reduce the happening of cardiovascular events.Methods:Randomly selected Affiliated Hospital of Qinghai University in November 2019 to November 2020 for 107 cases of primary group as class 3 patients with high blood pressure,high blood pressure,improve the 24-hour ambulatory blood pressure monitoring(ABPM),systolic blood pressure(24h SBP)record 24 hours,according to the formula to calculate the average real blood pressure variability(ARV),according to the 24 hsbparv hypertension group can be divided into three subgroups,low variability group(ARV < 9.8),the variation in the group(ARV between 9.8 to 12.8),high variation group(ARV > 12.8).At the same time,71 cases of Healthy people in our hospital were selected as the control group.All the subjects were asked general information such as gender,age,etc.,and the biochemical indexes such as blood glucose,triglyceride(TG),total cholesterol(TC),serum total bilirubin(TBIL)were collected from fasting blood samples.Urinary microalbumin(MALB)and urinary creatinine were measured and creatinine-urinary microalbumin/urinary creatinine(UACR)was calculated in uncontaminated mid-morning urine.The difference of UACR and TBIL between hypertension group and control group and different BPV subgroups was compared,and the relationship between BPV and UACR and TBIL was further analyzed.Results:1.UCAR level in the hypertension group was clearly higher than that in the control group(P < 0.05),and TBIL level in the hypertension group was lower than that in the control group(P < 0.05).There was no significant difference in sex,age,smoking proportion,BMI,blood glucose and TC between the two groups(P > 0.05).2.The levels of UCAR and TBIL were significantly different between hypertension subgroups(P < 0.05).With the increase of 24 h sbpbpv level,UACR level increased and TBIL level decreased.There were no significant differences in age,blood glucose,TG,TC and 24 h SBP among the three groups.(P > 0.05).3.Spearman correlation analysis showed a positive correlation between 24 h SBPBPV and UACR(r = 0.584,P < 0.01),and a negative correlation between 24 h SBPBPV and TBIL(r =-0.462,P < 0.01).Conclusion:1.The level of UACR in patients with grade 3 hypertension was higher than that in healthy people.With the increase of 24 h sbparv,the level of UACR increased.24 h sbpbpv is a risk factor for early renal damage,and independent of mean blood pressure.2.The level of TBIL in patients with grade 3 hypertension was lower than that in healthy people,and the level of TBIL decreased with the increase of 24 h sbparv.24 h sbpbpv is one of the factors affecting serum bilirubin.