Study On Abdominal Fat In Patients With Acute Pancreatitis Based On Quantitative CT

BackgroundIn recent years,the incidence of acute pancreatitis(AP)has been increasing.Previous studies have shown that obesity indicators such as body mass index(BMI)and waist circumference are related to the occurrence or severity of AP.With the continuous advancement of quantitative technology of abdominal fat,there are also many studies on the relationship between abdominal fat distribution or content and the severity of AP.However,there is a lack of systematization.At the same time,there are few studies on the relationship between abdominal fat content or distribution and AP at home and abroad.Objective1.To investigate the relationship between abdominal fat content or distribution(and BMI)and the occurrence of AP.2.To explore the parameters of abdominal fat(and BMI)that best judge the severity of AP disease and find out their value.Method1.Subject:Patients with acute abdomen admitted to Kaifeng Central Hospital from October 2019 to October 2020.According to the diagnosis,they were divided into two groups:AP group(n=81),control groupconsisted of non-AP patients(n=82).The AP group was divided into three subgroups according to the Revised Atlanta Classification Criteria:mild AP,moderate severe AP,and severe AP.2.Method:All patients checked by abdominal volume Computed Tomography(Scanning was performed with quantitative computed tomography(QCT)body membrane calibration).subcutaneous adipose tissue(SAT)area and visceral adipose tissue(VAT)area at the L2-3 level were collected.Then,the area of total adipose tissue(TAT)in the abdomen,ratio of visceral adipose tissue area to subcutaneous adipose tissue area(V/S),The percentage of visceral adipose tissue area to total adipose tissue area(VAT%)was calculated.At the same time,BMI,hypertension,diabetes,gallstone,cholecystitis and cholangitis,and hyperlipidemia situation of the patients was collected.3.Observation Index:(1)The differences of abdominal fat content or distribution(and BMI)between AP group and control group;(2)The differences of abdominal fat content or distribution(and BMI)among the 3 subgroups of AP patients;(3)The diagnostic efficacy of different abdominal fat content(and BMI)parameters on severe acute pancreatitis(SAP).Result1.There were statistically significant differences in VAT,TAT and BMI between the AP group and the control group(P<0.05),while no significant differences in SAT,V/S and VAT%(P>0.05);There was statistically significant differences in the prevalence of hyperlipidemia,and there were no statistically significant differences in the prevalence of hypertension,diabetes,cholecystolithiasis,cholecystitis and cholangitis(P>0.05).2.There were statistically significant differences in VAT,V/S and BMI among the 3subgroups of AP patients(P<0.05);There were no significant difference in SAT,TAT and VAT%(P>0.05).3.In the diagnosis of SAP in patients,VAT,TAT,V/S,VAT%and BMI were all of value(P<0.05),and the diagnosis efficiency of VAT was the best.4.The AUC value of VAT in diagnosis of SAP was 0.721,Youden index was 0.390,the corresponding specificity was 0.758,and sensitivity was 0.632;corresponding optimal threshold value of VAT is 219.80cm2.Conclusion1.QCT-based abdominal fat was associated with the occurrence and severity of AP.2.In the diagnosis of SAP,the diagnostic efficiency of VAT was better than the other parameters,and its optimal critical value is 219.8cm~2.VAT has important guiding significance in evaluation SAP and the outcome of AP in the clinical.