Brain Power Spectrum And Coherence Analysis Of Long-term Video-EEG In Children With Benign Epilepsy With Centrotemporal Spikes

BackgroundBenign Childhood Epilepsy with Centrotemporal Spikes(BECTS)is considered a benign epilepsy syndrome,that with central temporal spikes as a typical electroencephalogram(EEG)feature.In recent years,the quantitative analysis of brain electrical activity has been used to further study the brain electrical signals of BECTS patients,and the results suggest that the brain electrical signals of BECTS patients are obviously abnormal.However,it remains a challenge to analyze the brain power spectrum and EEG signal coherence of BECTS patients under different conditions.The purpose of this study is to analyze the long-term video EEG of patients with BECTS in different states,and to further explore the characteristic changes of EEG signals of patients with BECTS,so as to provide a basis for BECTS-related tests.ObjectiveTo analyze the characteristics of brain power spectrum and coherence analysis of long-term video EEG in patients with BECTS.MethodsA total of 47 patients who have completed long-term video EEG examination were diagnosed as BECTS in the first affiliated Hospital of Xinxiang Medical College from January 2017 to October 2020 were included in the case group.In addition,completed the long-term video EEG and Computed Tomography/Magnetic Resonance Imaging at the first affiliated Hospital of Xinxiang Medical College in the same period which had no obvious abnormality reviewed by two or more attending doctors.those who had no seizures in the past and matched with the demographic data of the experimental group were included in the control group.Based on Matlab software,the brain power spectrum and coherence values of all subjects’ long-range video-EEG were retrospectively analyzed.Results1.Brain power spectrum:Compared with the control group,the absolute power of most brain areas(except the left occipital area of θ and δ waves)in the case group increased significantly at specific frequencies during sleep,and the difference was statistically significant(P < 0.05).During the awakening period,except for the lower occipital lobe,parietal lobe,middle and posterior temporal and central areas in α,θ,and γbands,the absolute power of all brain areas increased significantly at other specific frequencies,and the difference was statistically significant(P < 0.05).2.Coherence analysis:High coherence: Compared with the control group,during the awakening period,there was high coherence in the case group between the central area and the temporal area,the central area and the parietal-occipital area in δ,θ,α and βbands.While during the sleep period,there was high coherence among brain areas in θ,αand β bands,bilateral central areas in δ band,central area,temporal area and parietal occipital area in γ band(P < 0.05).Low coherence: Compared with the control group,during the awakening period,there was low coherence in the case group between the central area and the frontal lobe in α and γ bands(P < 0.05).While during the sleep period,there was low coherence among the corresponding brain areas of the left and right hemispheres except the frontal lobe in θ band,between the temporal regions on both sides in α band,and between the central area and the frontal area in γ band(P <0.05).Conclusions1.The brain power spectrum of BECTS showed a diffuse increase in the whole brain.2.The temporal,central and frontal areas of BECTS showed low coherence,while most of the other brain areas showed high coherence.