Quality Evaluation Of Clinical Evidences About Preventions For Cytomegalovirus Infection After Renal Transplantation

Objective: Cluster analysis of cytomegalovirus infection after renal transplantation related literature research status and research hotspots,systematic analysis of cytomegalovirus infection after renal transplantation preventive clinical research evidence methodology and report quality,to provide methodological support for in-depth research and achievement transformation.Methods:1)Bibliometric analysis: using the software of COOC 9.9 and vosviewer 1.6.10 to analyze the related research on cytomegalovirus infection after renal transplantation at home and abroad,and explore the current research status and hot spots of cytomegalovirus infection after renal transplantation;2)Quality evaluation of randomized controlled trials:the quality of reports on prevention of cytomegalovirus infection after renal transplantation was evaluated by CONSORT 2010 statement;3)Overview:AMSTAR scale was used to evaluate the methodological quality of the SR/MA analysis on the prevention of cytomegalovirus infection after renal transplantation.PRISMA scale was used to evaluate the reporting quality of the SR/MA on the prevention of cytomegalovirus infection after renal transplantation.Results:1)Research status of cytomegalovirus infection related literature after renal transplantation: cytomegalovirus pneumonia and its treatment after renal transplantation,epidemiology of cytomegalovirus infection,diagnosis and treatment of cytomegalovirus infection,detection of cytomegalovirus infection,risk factors of cytomegalovirus infection are the current research hotspots.2)Finally,46 RCTs related to cytomegalovirus prevention after renal transplantation were included.The results of consort 2010 statement showed that 17 studies of the abstracts and introductions fully reported the topics,31 studies fully reported the abstracts according to the structure,and only 1 study did not fully report the relevant background knowledge;In the part of methodology,19 studies fully reported the eligibility criteria of the subjects,45 studies fully reported the intervention measures,and40 studies did not report the determination of the sample size of the subjects;In the randomized part,11 studies reported the method of random allocation,5 studies fully reported the type of random method,43 studies did not report the hidden mechanism of allocation and the implementer of the trial,and only 1 study reported the implementation of blind method;In the results section,only 11 studies reported the inclusion process of subjects according to the flow chart,and 19 studies reported the number and reasons of subjects being excluded after grouping;In the discussion part,37 studies fully explained the results,and only 11 studies reported the limitations of the trial;In the other information section,8 studies were registered before the trial,and 18 studies reported funding sources.3)A total of 9 SR/MA on the prevention of cytomegalovirus infection after renal transplantation were included.The results of AMSTAR tool evaluation show that scale has5-9 scores,average score of 7 points,and medium quality.There is no one design plan included in the study report and the list of excluded documents,and 9 studies have repeatability on the selection and data extraction of the included research,Only one study report has not been comprehensively searched,2 Gray studies are included,only one study is not reported in the study feature description,one study has not been evaluated and reported to be scientific,and 9 studies have scientifically deduced conclusions,There are 2studies that have not evaluated the possibility of publication bias,only 3 studies show the source of funds and no related conflicts of interest.PRISMA was used to evaluate the quality of the reports included in the study.The results show that the score of prism evaluation tool is between 13-23,with an average score of 18.3,and the overall quality of the research report is moderate,of which only one document is more than 21,the report is relatively complete,two studies are less than 15 points,and the report has relatively serious defects,including the research benchmarking question,theoretical basis,summary effect index,and The comprehensive analysis method,research characteristics,single research results,combined results,conclusion are fully reported.Almost all the results of analysis are not reported in the study for the scheme and registration,retrieval,and other analysis results.Conclusions: At present,the research hotspots of cytomegalovirus infection after renal transplantation focus on cytomegalovirus pneumonia and its treatment,epidemiology of cytomegalovirus infection,diagnosis and treatment of cytomegalovirus infection,detection of cytomegalovirus infection,and risk factors of cytomegalovirus infection.the quality of reporting standard of randomized controlled trials related to the prevention of cytomegalovirus infection after renal transplantation is poor,and it still needs to be further improved.However,the methodological quality and reporting quality of SR/MA on the prevention of cytomegalovirus infection after renal transplantation are medium,which need to be improved.The existing RCTs related to cytomegalovirus infection after renal transplantation are difficult to be transformed into SR/MA with higher level of evidence,so it is necessary to evaluate the quality of included Sr and select high-quality SR for re evaluation.