Analysis Of The Relationship Between The Detection Of Plasma CfDNA Methylation By Electrochemical Method And The Diagnosis Related Clinical Features Of Thyroid Cancer

ObjectiveThe value of plasma circulating free DNA(cf DNA)methylation in the diagnosis of thyroid cancer and its correlation with TI-RADS grade and clinicopathological features were determined by electrochemical method.MethodsSelect 114 cases of patients with thyroid cancer and 35 patients with thyroid benign lesions and 35 normal controls and extract circulating free DNA in plasma by electrochemical method to detect the plasma free DNA(cf DNA)level of current adsorption rate(ir),analysis of the current adsorption rate in patients with thyroid carcinoma,benign lesions and normal differences,and analyze the adsorption rate and the clinical pathological features and thyroid impact report and data between systems classification(TI-RADS hierarchical)relationships.ResultsThe ir value of thyroid cancer patients was higher than that of benign lesions patients(P<0.05),AUC=0.778.The plasma IR value of thyroid cancer patients was higher than that of normal subjects(P<0.05),and AUC=0.723.There was no significant difference in ir between patients with benign thyroid lesions and normal controls(P=0.094).The sensitivity,specificity and accuracy were 61.4%,68.6% and 64.1%,with statistically significant differences(P <0.05).There was no statistically significant difference in tumor size,lymph node metastasis,local invasion and multi-centrality between the ir value <29 group and the ir value ≥29group(P>0.05).ir value ≥29 was an independent risk factor for thyroid cancer OR=1.244(P<0.01).ConclusionPlasma cf DNA current adsorption rate(ir value)has certain significance in the diagnosis of thyroid cancer.ir≥29 was an independent risk factor for thyroid cancer.Plasma cf DNA current adsorption rate(ir value)was correlated with TI-RADs grading.