Study On The Correlation Between Vitamin K Deficiency And Abnormal Bone Metabolism In Children

Objective Children explore the correlation of vitamin K levels and bone metabolic abnormalities in,whether through the influence of vitamin K on bone metabolism,to its early diagnosis,early prevention,reasonable intervention,so as to prevent the happening of the bone metabolic diseases,for the clinical prevention and intervention,establish a lack of vitamin K in China and intervention evaluation provides the data,provide support for the optimization of diagnosis and treatment,at the same time for vitamin K further in-depth study of correlation with bone metabolism and provide evidence-based and data support.Methods A total of 42 children with reduced bone mineral density(abnormal bone metabolism group)and 50 children with normal bone metabolism(normal control group)were collected from our hospital on January 1,2019 with solstice and results of reduced bone mineral density(abnormal bone metabolism group)on December 31,2019.High performance liquid chromatography tandem mass spectrometry was used to determine the concentration of vitamin K,and the levels of vitamin K were compared between the two groups.Logistic regression analysis was used to analyze the risk factors of bone metabolism and related factors,and to explore the correlation between vitamin K deficiency and the occurrence of abnormal bone metabolism.Results1.Vitamin K deficiency in the cases in this study was mainly vitamin K2 deficiency.Blood vitamin K2 deficiency accounted for 73.9%(68/92)of all subjects,and vitamin K1 deficiency was only 2.2%(2/92).2.The incidence of vitamin K2 deficiency was 90.5%(38/40)in the group with abnormal bone metabolism,and 60%(30/50)in the group with normal bone metabolism.The difference between the two groups was statistically significant(P<0.05).Vitamin K2 deficiency was not related to age,sex,height,weight,vitamin D3,Ca,P,alkaline phosphatase(P > 0.05)3.The concentration of vitamin K2 in the abnormal bone metabolism group was 0.030(0.020-0.065)ng/ m L,and that in the healthy control group was 0.080(0.070-0.310)ng/m L,respectively,and the difference was statistically significant(P <0.05).4.Logistic regression analysis showed that vitamin K2 deficiency(OR = 0.158,95%CI = 0.009-0.646,P=0.018)was an independent influencing factor for the occurrence of abnormal bone metabolism in children.5.ROC curve indicates that vitamin K2 level alone(< 0.055ng/ml)has a high predictive value for abnormal bone metabolism in children.Conclusion:1.Vitamin K deficiency was found in local children in this study.Vitamin K deficiency in children is mainly vitamin K2 deficiency.Vitamin K2 deficiency was as high as73.9%,while vitamin K1 deficiency was only 2.2%.2.Vitamin K2 levels affect bone metabolism in children.The incidence of vitamin K2 deficiency and blood vitamin K2 concentration in children with abnormal bone metabolism were significantly different from those in children with normal bone metabolism(P < 0.05),3.Vitamin K2 deficiency may be one of the independent risk factors for the occurrence of abnormal bone metabolism(OR=0.158).4.The detection value of vitamin K2 concentration may have predictive value and auxiliary diagnostic value for whether children have abnormal bone metabolism.However,further studies with large samples and multiple centers are needed.