Analysis Of The Meaningness Of Exhaled Nitric Oxide Among Clinical Characteristics Of Chronic Obstructive Pulmonary Disease And Its Pulmonary Comorbidities

Objective: The purpose of this study was to explore the change of FeNO in chronic obstructive pulmonary disease and pulmonary comorbidities,so as to provide possible evidence for individualized clinical diagnosis and treatment of chronic obstructive pulmonary disease and its comorbidities.Methods: the clinical data of patients with COPD in the affiliated Hospital of Guilin Medical College from June 2018 to June 2020 were analyzed retrospectively.After screening,a total of 176 patients met the inclusion criteria and exclusion criteria.General clinical data and indexes such as FeNO,pulmonary function,cardiac color ultrasound,chest HRCT and routine biochemical tests were collected.The groups can be divided into three groups according to the number of lung comorbidities:COPD group;COPD with single pulmonary comorbiditie group including pulmonary hypertension group,bronchiectasis group,asthma group and lung cancer group;COPD with 2 and upper pulmonary comorbidities group,to analyze whether there are differences in the above data among the groups,and to explore its clinical significance.Results: a total of 176 patients with COPD were included in the study.1.Comparison between groups of chronic obstructive pulmonary disease complicated with single pulmonary comorbidities.1)There was significant difference in age between groups(P<0.05).The age in group with pulmonary hypertension was higher than that in other subgroups,but there was no significant difference in sex,BMI and history of smoking exposure.2)Blood routine analysis showed that there was significant difference in hemoglobin among the groups(P<0.05).The hemoglobin in the lung cancer group was lower than that in the bronchiectasis group and asthma group.3)There was no significant difference in pulmonary function among the groups.4)There was no significant difference between high and low FeNO in COPD complicated with single pulmonary comorbidities(P>0.05).2.The comparative analysis of COPD with different numbers of pulmonary comorbidities showed that 1)there was significant difference in gender among COPD with different numbers of pulmonary comorbidities,and it was more common in females with 2 or more pulmonary comorbidities groud(P<0.05),but there was no significant difference in age and BMI among groups.2)the results of blood routine analysis among COPD patients with different numbers of pulmonary comorbidities showed that there was significant difference in hemoglobin between two or more pulmonary comorbidity groups(P<0.05),and hemoglobin in two or more pulmonary comorbidity groups was lower than that in the other two groups.3)There was no significant difference in pulmonary function and FeNO.3.There was no significant difference in FeNO between the grades of pulmonary function in COPD group(P>0.05).4.There was no significant difference in age,blood routine,FeNO and pulmonary function between the two groups in the severity of COPD complicated with pulmonary hypertension.5.There was no significant difference in age,blood routine,FeNO and pulmonary function among the subgroups of COPD complicated with lung cancer.Conclusion: Based on the data of this retrospective study,1.There was no significant correlation between the number of COPD complicated with pulmonary comorbidities and FeNO.2.There was no significant correlation between the severity of COPD complicated with pulmonary hypertension and FeNO.3.There was no significant correlation between the severity of pulmonary function of COPD and FeNO.4.There was no significant correlation between FeNO and COPD patients with different types of lung cancer.To sum up,it is suggested that FeNO is of great value in the individual diagnosis and treatment of chronic obstructive pulmonary disease and its pulmonary comorbidities.