Analysis Of Risk Factors Of Renal Involvement And Evaluation Of Hemoperfusion In Children With Henoch-Schonlein Purpura

Objective: To study the risk factors of renal involvement in children with Henoch-Schonlein purpura and evaluate the efficacy of hemoperperfusion in Henoch-Schonlein purpura.Methods: Children with initial HSP hospitalized in the department of Pediatrics,Lanzhou University First Hospital from January 2018 to July 2019 were selected as study subjects,and were divided into the HSPN group(45 cases)and the HSP group(103 cases)according to the presence or absence of renal involvement.Then,whether the HSPN group had received HP treatment was divided into two subgroups: the conventional treatment group(33 cases)received only drug treatment,and the HP group(12 cases)received drug and HP treatment.Through clinical data and follow-up data collection,classification variables using chi-square test,numerical variables if meet the homogeneity of variance criterion using independent sample t test,if the variance is not neat,is using single factor analysis of nonparametric rank and inspection,then the statistically significant variables using logistic regression analysis,so as to find out for the first time the risk of HSP children progress of HSPN factors,and to evaluate the therapeutic effect of HP.Results:1.There were statistically significant differences between the HSPN group and the HSP group in age ≥7 years old,living in rural areas,recurrent rash ≥2 times,purpura distribution range ≥26%,abdominal pain,gastrointestinal bleeding,duration of gastrointestinal symptoms ≥5 days,and length of hospital stay ≥6 days,ect.(P<0.05);There were statistically significant differences in peripheral blood albumin decrease,Ig G decrease,C4 decrease,TC increase,TG increase,urinary microalbumin increase,NAG increase,etc.(P< 0.05).2.Recurrent rashes ≥2 times,gastrointestinal bleeding and elevated serum TG were independent risk factors for renal injury in children with HSP,and the differences were statistically significant(P< 0.05).3.After the treatment of HP group,the proportion of rashes,gastrointestinal symptoms,reduced joint symptoms and length of stay(<6 days)was higher than that of the conventional treatment group,with statistically significant differences(P<0.05).Conclusion:1.Recurrent rashes ≥2 times,gastrointestinal bleeding and elevated serum triglyceride in children with Henoch-Schonlein purpura have the risk of renal involvement,so follow-up and monitoring should be strengthened.2.Hemoperfusion has a good therapeutic effect on children with acute severe skin rash,severe digestive symptoms and joint swelling and pain.