Meta-analysis Of The Expression And Clinical Significance Of AEG-1 In Gastric Cancer Tissues

Objective:To investigate the diagnostic value of astrocyte elevated gene-1(AEG-1)in gastric cancer and the correlation between the expression of AEG-1 and the clinicopathological features of gastric cancer Methods:A comprehensive search of online literature databases such as Pub Med,Embase,The Cochrance Library,Web of Science,CNKI,Wanfang,and Vipshop was conducted to collect relevant literature,and the search period was from the date of creation to October 15,2020.The literature was screened according to the inclusion and exclusion criteria,the required data were extracted,and Meta-analysis was performed using Revman 5.3 and Stata 12.0 software.Results:A total of 1233 patients with gastric cancer were included in the analysis.The Meta-analysis showed that relatively higher risk of AEG-1 overexpression in gastric cancer tissues compared to non-gastric cancer tissues [OR=9.30,95%CI(5.45,15.89),P<0.00001].In terms of clinicopathological features,AEG-1 overexpression was found in gastric cancer plasma membrane layer infiltration[OR=3.98,95%CI(2.82,5.63),P<0.00001],hypofractionation [OR=3.14,95%CI(2.04,4.82),P<0.00001],lymphnode metastasis [OR= 3.90,95%CI(2.15,7.05),P<0.00001],and poorer TNM staging [OR=4.01,95% CI(2.31,6.94),P< 0.00001].While there was a higher risk associated with gender [OR=0.99,95% CI(0.76,1.29),P = 0.95],age [OR = 0.85,95% CI(0.64,1.12),P=0.25],tumor size [OR = 1.20,95% CI(0.87,1.66),P=0.28],Lauren’s staging[OR=1.36,95% CI(0.51,4.08),P=0.49]were not significantly associated.Conclusion:AEG-1 protein is overexpressed in gastric cancer tissues and may be a promising biomarker for gastric cancer.Overexpression of AEG-1 may be involved in the invasion,metastasis and differentiation of gastric cancer,which may lead to the identification of new potential therapeutic targets.