Case Analysis Of Cardiorenal Syndrome Type 3

Objective:Cardiorenal syndrome type 3(CRS 3)is a cardiac injury and/or dysfunction caused by acute kidney injury(AKI).This study will retrospectively analyze the hospitalization data of AKI patients to clarify the epidemiological characteristics of CRS3.At the same time,we will also analyze the risk factors and its impact of CRS 3 in the AKI patients,so as to prevent and identify the CRS 3,taking active and effective measures to improve the prognosis of AKI patients.Methods:The retrospective case-control study of inpatients in a single center,Four hundred and six AKI patients who received treatment in the second hospital of Shanxi Medical University from January 1,2017 to October 1,2020 were included in the study,and the database was established by spss25.0 software.The basic information,past medical history,results of laboratory tests and examinations,number of days in hospital,amount of expenses and outcome at discharge were recorded in detail.According to the occurrence of acute cardiovascular events during hospitalization,the patients were divided into cardiorenal syndrome type 3 group(63 cases)and AKI group(343 cases).Then,we compared the data of the two groups,using x~2test,t test,single factor correlation analysis,two-class multivariate logistic regression analysis model to analyze the occurrence and risk factors of CRS type 3 in AKI patients,the impact on the prognosis of AKI patients.Results:Among 406 patients with AKI,63(15.52%)developed CRS 3.Among the cardiovascular events,acute heart failure(44.44%)accounted for the highest proportion;(2)AKI stage(stage 1/2/3:7/11/45 vs 119/68/156),neutrophil percentage[73.0%(46/63)vs 39.9%(137/343)],high sensitivity troponin[50%(30/60)vs 12.0%(35/343)],NT-pro BNP[91.7%(55/60)vs 42.8%(125/292)],metabolic acidosis[44.2%(23/52)vs15.9%(46/289)],renal replacement therapy[44.4%(28/63)vs 14.3%(49/343)]were statistically different between the two groups(all P<0.001).Binary multivariate logistic regression analysis(stepwise regression method)showed that:increased high sensitivity troponin(OR=3.707,95%CI:1.896-7.249,P<0.001)and NT-pro BNP(OR=9.054,95%CI:3.418-23.983,P<0.001)were independent risk factors for CRS 3 in AKI patients;(3)CRS 3 had adverse effects on the prognosis of patients,and the length of hospital stay and cost of CRS 3 group were higher than AKI Group.Conclusion:The incidence of CRS 3 is high in AKI patients.High sensitivity troponin and NT-pro BNP are independent risk factors for CRS 3 in AKI patients.In clinical work,we should make account of the possible cardiovascular events to prevent and identify it early,and take different measures to delay the progress of cardiovascular complications,preventing the deterioration of the disease and multiple organ failure.