Study On The Correlation Between IL-6 And IL-8 Levels In Induced Sputum Of COPD Patients And Inflammatory Phenotypes

Objective:Chronic obstructive pulmonary disease(COPD)is a highly heterogeneous disease with different inflammatory manifestations in different individuals.The COPD phenotype is a characteristic of one or more diseases and can point out the differences between different COPD patients.The eosinophil phenotype is a unique inflammatory phenotype of COPD.Induced sputum is a non-invasive airway sampling method.This study aims to investigate the correlation between induced sputum levels of interleukin-6(IL-6)and interleukin-8(IL-8)and inflammatory phenotype in COPD patients,so as to provide theoretical basis and monitoring indicators for precise treatment of COPD patients.Methods:A total of 30 patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)and 30 patients with stable COPD(SCOPD)were selected from Fenyang Hospital of Shanxi Province from December 2019 to June 2020.All selected patients underwent pulmonary function and induced sputum examination.The general data of enrolled patients,FEV1 / FVC,classification of cells in induced sputum,IL-6,IL-8.Analyze the correlation between the levels of IL-6 and IL-8 in induced sputum and the acute exacerbation,GOLD grade and inflammatory phenotype of COPD patients.Results:The levels of IL-6 and IL-8 in induced sputum of AECOPD patients were significantly higher than those of SCOPD patients(P<0.05);they were positively correlated with GOLD classification(P<0.05).According to the classification of induced sputum cytology,27 cases(45%)of eosinophilic type and 33 cases(55%)of non-eosinophilic type were classified in this study.There are differences in the expression of IL-6 and IL-8 in different inflammatory phenotypes: non-eosinophilic> eosinophilic(P<0.05).Conclusion:Levels of IL-6 and IL-8 in induced sputum of COPD patients correlated with acute exacerbations in COPD patients,positively correlated with GOLD grade,and low expression in the eosinophilic phenotype than in the noneosinophilic phenotype.