| Objective: This study aims to investigate the clinical manifestations,chest CT results and tidal breathing pulmonary function characteristics in infants with mycoplasma pneumoniae(MP)associated asthmatic pneumonia at the acute stage,as well as the time of cough disappearance and the change in pulmonary function parameters at the recovery stage so as to guide the early diagnosis of MP infection in clinical practice and to understand the damage and recovery of pulmonary function in infants with MP associated asthmatic pneumonia.Method: A total of 171 children who were admitted to Paediatrics of our hospital from January 2019 to December 2020 met the inclusion criteria and have been enrolled in the present study.According to the MP-Ig M results,they were divided into MPP group and non-MPP group.Clinical manifestations,chest CT results and tidal breathing pulmonary function parameters were observed and compared between the two groups.The children were followed up 1 month after discharge,the time of cough disappearance and the tidal breathing pulmonary function parameters were compared between the two groups.Results:1.The difference in average height(84.39±11.56 vs 81.39±9.97)cm,mean weight(12.34±3.12 vs 11.64±2.75)kg,mean age(19.18±9.03 vs 17.73±9.76)months,sex distribution of boys to girls(37/46 vs 54/46)and so on general information was not statistically significant(P>0.05)between the MPP group and non-MPP group.The two groups were comparable.2.The difference in cough time(4.74±2.89 vs 5.28±3.15)days before admission,cough symptom scores(2.28±0.72 vs 2.22±0.70)points,fever(14/55 vs 25/77)cases,fever days(1.86±0.86 vs 2.48±1.58)days,body temperature peaks(38.54±0.68 vs38.64±0.59)℃and so on clinical manifestations was not statistically significant(all P>0.05)between the MPP group and non-MPP group.The difference in length of stay(7.23±1.39 vs 7.24±1.68)days was not statistically significant(P>0.05)between the two groups.Compared with the time of cough disappearance after discharge,the difference was not statistically significant(P>0.05)between the two groups.Both groups had the most common chest CT results,including lung patch shadows and increased and thickened lung markings.The difference was not statistically significant(P>0.05).3.In the acute phase of asthmatic pneumonia,the pulmonary function parameters TPTEF/TE,VPTEF/VE and Ti/Te decreased significantly in the two groups.VT/kg was in a normal range.TPTEF/TE(18.12±5.60)% and VPTEF/VE(22.16±4.59)% of MPP group were lower than TPTEF/TE(21.34±5.28)% and VPTEF/VE(24.47±4.55)% of non-MPP group.The difference was statistically significant(all P<0.05).The difference in pulmonary function parameters VT/kg(8.74±1.49 vs 8.67±1.34)ml/kg,Ti/Te(0.62±0.09 vs 0.64±0.10),PTEF(120.00±28.84 vs 120.37±34.28)ml/s,TEF75(117.26±29.51 vs 117.34±35.20)ml/s,TEF50(97.19±22.95 vs 97.37±27.51)ml/s and TEF25(66.97±16.23 vs 66.07±18.33)ml/s was not statistically significant(all P>0.05)between the MPP group and non-MPP group.4.In the acute phase of asthmatic pneumonia,the airway obstruction varied and the difference was statistically significant(P<0.05)between the two groups.The airway obstruction was moderate to severe in the MPP group while the airway obstruction was mainly mild to moderate in the non-MPP group.There was no restrictive ventilation dysfunction in both groups.5.In the recovery phase of asthmatic pneumonia,the TPTEF/TE(24.32±5.11%)and VPTEF/VE(25.73±4.59%)of MPP group were significantly lower than TPTEF/TE(28.57±6.75%)and VPTEF/VE(30.34±6.46%)of non-MPP group.The difference was statistically significant(all P<0.05).Whereas the difference in pulmonary function parameters VT/kg(8.26±1.09 vs 8.51±1.17)ml/kg,Ti/Te(0.68±0.09 vs 0.70±0.09),PTEF(114.58±16.43 vs 111.49±15.34)ml/s,TEF75(112.80±16.66 vs 110.75±15.31)ml/s,TEF50(89.62±13.31 vs 88.69±13.99)ml/s and TEF25(65.62±9.46 vs65.80±12.91)ml/s was not statistically significant(all P>0.05)between the MPP group and non-MPP group.The TPTEF/TE,VPTEF/VE and Ti/Te of non-MPP group returned to a normal level.However,the TPTEF/TE and VPTEF/VE of MPP group were still lower than the normal level,but the Ti/Te returned to normal.Conclusions:1.There was no significant difference in clinical manifestations,length of stay and chest CT results between the MP infection and non-MP infection induced asthmatic pneumonia infants.2.In the acute stage of asthmatic pneumonia,MP infection exacerbates lung injury,and the incidence of moderate to severe airway obstruction is higher.3.In the recovery phase of asthmatic pneumonia,the recovery of lung function caused by MP infection is delayed.There is a persistent phenomenon of small airway obstruction with delayed recovery. |
PDF Full Text Request