Clinical Observation Of Buyang Huanwu Decoction In The Treatment Of Ischemic Apoplexy With Qi Deficiency And Blood Stasis In Convalescence

1 PurposeThrough a randomized controlled case study,the clinical efficacy of Buyang Huanwu Decoction in the treatment of ischemic stroke with qi deficiency and blood stasis(convalescence)was observed,and its mechanism of action was preliminarily explored.2 MethodThe study participants were derived from maternal and child health hospital affiliated to anhui medical university,2 families,selected in 2018 hospitalized during October to November 2019 in ischemic stroke(recovery)diagnosis and syndrome differentiation of traditional Chinese medicine to 80 patients with qi deficiency blood stasis all subjects using the random number table method divided into treatment group and control group,40 cases in each group after all subjects into groups based on the medical treatment on a regular basis: the control group given top,treatment(biological engineering of Harbin pharmaceutical group co.,LTD.,approved by H20084565),usage and dosage: 0.9%NaCl100ml+ alprostadil 10 ug,static drops once a day;In the treatment group,on the basis of the treatment in the control group,buyang Huanwu Decoction was added for treatment.Usage and dosage: decocted in water for internal consumption,1 dose per day,taken twice,100 ml each time.After two weeks of continuous medication,TCM syndrome score,neurological impairment score,motor function score,and Activity of Daily Living(ADL)evaluation were compared between the two groups before and after treatment.Serum levels of interleukin-1 beta(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and matrix metalloproteinases-9(MMP-9)were compared,and the general baseline data and drug safety were compared between the two groups.This experiment was approved by the Ethics Committee of the Maternal and Child Health Hospital affiliated to Anhui Medical University and carried out after patients’ informed consent was signed.3 Results(1)During the test,4 patients in the treatment group and 3 patients in the control group lost their weight.Finally 36 effective subjects were completed in the treatment group and 37 in the control group.After 2 weeks of treatment,36 cases in the treatment group,7 cases were basically cured,14 cases showed obvious effects,10 cases were effective,and the total effective rate was 86.11%.In the control group,37 cases were basically cured in 4 cases,obvious in 12 cases,effective in 8 cases and ineffective in 10 cases,with a total effective rate of 64.86%.Compared with the control group,the total effective rate of the treatment group was significantly increased,with statistically significant difference(P<0.05).(2)After 2 weeks of treatment,TCM syndrome scores in both the treatment group and the control group decreased to different degrees(P<0.05),and the decrease in the treatment group was more significant than that in the control group(P<0.05).Besides,scores of Neurological Deficits were decreased to different degrees in both the treatment group and the control group(NIHSS)(P<0.05),and the decreases were more significant in the treatment group than in the control group(P<0.05).The motor function(Fugl-Meyer,FMA)scores of the treatment group and the control group were increased to different degrees(P<0.05),and the increase in the treatment group was more significant than that in the control group(P<0.05).The Activity of Daily Living(ADL)score of the treatment group and the control group increased to different degrees(P<0.05),and the increase was more significant in the treatment group than in the control group(P<0.05).(3)The serum levels of IL-1β,IL-6,TNF-α and MMP-9 were not significantly different between the two groups before treatment(P>0.05).After 2 weeks of treatment,the expressions of IL-1β,IL-6,TNF-α and MMP-9 in the treatment group and the control group were decreased to different degrees(P<0.05),and the decrease in the treatment group was more significant than that in the control group(P<0.05).4 ConclusionBuyang Huanwu decoction has significant clinical efficacy in treating ischemic stroke patients with qi deficiency and blood stasis(convalescence),and has positive effects on the repair of neurological deficit and motor function,and improvement of activity in daily life in patients.Moreover,the mechanism of action may be related to the improvement of the level of inflammation in patients.