Associations Between Serum BDNF,MG Levels And Mild Cognitive Impairment In Patients With OSAHS

Objective:To study the correlation between the serum brain-derived neurotrophicfactor（BDNF）,methylglyoxal（MG）and Mild cognitive impairment in patients with obstructive sleep apnea hypopnea syndrome（OSAHS）,to explore its clinical application value.Method:A total of 82 adult patients with suspected OSAHS admitted to the Affiliated Hospital of Chengde Medical College from May 2020 to December 2020 and adult physical examinations during the same period were selected.All subjects filled out the Epworth Sleepiness Scale（ESS）Parallel overnight polysomnography（PSG）or portable monitoring（PM）After monitoring,they were divided into OSAHS and control group.Then,they filled out the Montreal Cognitive Assessment（Mo CA）for cognitive assessment.The fasting venous blood was drawn in the morning of the next day.The serum BDNF is detected by ELISA method,and MG is detected by high performance liquid chromatography.The correlation between BDNF and MG and cognitive scores was analyzed and compared.Results:1.The OSAHS group included 52 OSAHS patients with an average age of（48.040±1.888）years and an average education level of[12（9,15）]years;the control group included 30 physical examination subjects,24 males（80.0%）,and average age（48.400±1.617）years old,average education level[12（12,15）]years.There was no statistically significant difference in age,gender,education level,BMI,hypertension,hyperlipidemia,and coronary heart disease between the two groups.The baseline data are comparable.2.OSAHS group sleep apnea hypopnea index（AHI）,Lowest Sa02（La S_PO₂）decreased,and ESS score increased,which was statistically different from the control group（P<0.05）.3.Compared with the control group,the total MOCA score,delayed recall,visual space and executive ability,language,abstraction,and attention scores in the OSAHS group were significantly reduced（P<0.05）,while the naming and orientation scores were not significantly different（P>0.05）.4.The peripheral serum BDNF level of the OSAHS group was[19.086（11.592,25.629）]ng/m L,while the control group was[18.786（13.312,24.224）]ng/m L.Although the BDNF level of the experimental group increased to a certain extent,the two groups The difference was not statistically significant（P>0.05）;the serum MG of the OSAHS group was[3.621（2.312,4.598）]ng/m L,andthecontrolgroupwas[6.149（3.894,19.726）]ng/m L.The serum MG level of the OSAHS group was Compared with the control group,it was significantly reduced（Z=-3.851,P=0.000）,and the difference was statistically significant.5.Between serum BDNF level and Mo CA score was no correlation（P>0.05）in OSAHS group;OSAHS group serum MG level was positively correlated with Mo CA total score,delayed recall,visual space,and executive ability scores（r=0.286,P=0.04;r=0.286,P=0.04;r=0.308,P=0.026）,there is no correlation with naming,abstraction,attention,orientation,language（P>0.05）.Conclusion:1.OSAHS patients may be prone to complicated with mild cognitive impairment.2.Changes in serum BDNF and MG levels may be inseparablely associated with the arise and development of OSAHS.3.The decrease of serum MG level is closely related to the impaired cognitive function of OSAHS patients.