Impairment Of Cognitive Function In A Population At High-risk For Sleep Apnea:A Resting And Task-state Brain Imaging Study

Obstructive sleep apnea is one of the most common sleep disorders,mainly since the upper respiratory muscles of the upper respiratory tract in the night sleep cause the local or complete obstruction of the respiratory tract to the occurrence of low ventilation or apnea.The brain is the most oxygen-consuming organ,and any physical activity and cognitive activity require sufficient oxygen,which can be easily associated with chronic damage to the brain when the body is in a low blood oxygen state and may threaten the health of life over time.Around 1 billion adults around the world are likely to have OSA,and China’s potential number of potential patients is likely to be the most.Cognitive function is the ability of people to realize the understanding and understanding of foreign things,which plays an indispensable role in normal social life and survival,and its functional damage directly affects the production life of people and even survival.Working memory is one of the important components of cognitive function,which is widely concerned and is considered the core hub of cognitive function.The long-term low blood oxygen state of OSA patients can damage the brain to damage cognitive function,and the decline of patient working memory ability has been reported.Therefore,screening and diagnosis of disease are very important for the reduction of cognitive function in patients with preventive and mitigation.The traditional method of screening for OSA is tedious and costly,and it is difficult for people to know less about the disease,the science,and the screening of the disease.Therefore,it is important to find a tool that can measure the risk of individual problems more effectively and distinguish between high-risk groups and healthy people,and the high-risk groups that have been tested by multidimensional tests are indeed prone to brain damage and decreased function,which can better explain the severity of the disease.Currently,the mainstream scale for OSA screening is the stop-bang scale,and to explore whether the two groups between the stop-bang scale are different in brain activity and function,we have conducted the following three experimental studies:The study was conducted on the first screening of the recruited test,which was divided into high-risk groups and low-risk groups,and evaluated the sleep conditions of the two groups of people in different dimensions and the three nervous psychological scale to evaluate the emotional state of the two groups and the cognitive function,and the differences and correlation between the groups that were scored by the SPSS analysis scale.The results showed that the scores of the two groups were more significant in most indicators.The quality of sleep in high-risk groups was significantly lower than that of the low-risk group,and the cognitive function of the low-risk group was significantly higher than that of the high-risk groups,but there was no significant difference in the emotional characteristics of the two groups.In relation,the sleep scale score and Mo CA score were highly negative,indicating that low sleep quality could damage cognitive function.In this paper,the change of brain activity in the resting state of high-risk groups was analyzed by using magnetic resonance imaging technology based on the function of the static state.But based on the analysis of local indexes and the functional connectivity analysis based on 264 ROI,there was no significant abnormal activity in the brain of high-risk groups compared to low-risk groups.The study also uses face graphics as the “n-back” paradigm of the stimulus material and also uses the magnetic resonance imaging technique(functional magnetic resonance imaging,f MRI)to explore whether the brain activity in the process of completing the task of working memory is explored.The behavioral data from the relevant behavior showed that there was an interaction between the risk and difficulty of the risk and task in the analysis of the accuracy(accuracy,Acc),and the main effect of the two variables was significant,indicating that the rate of accuracy of the high-risk group was more pronounced as the task was more difficult and that there was no significant difference in the analysis of the response time(RT)analysis.The results from the brain image showed that the high levels of brain activity in the working memory mission were significantly lower than the low-risk groups,and the brain areas of the frontal lobe,occipital lobe,and fusiform gyrus were more obvious,but they did not detect the interaction between the risk of the disease and the difficulty of the task.In conclusion,bad sleep can damage cognitive function,and chronic sleep disorder can significantly change the cognitive and brain activity of the brain.Stop-bang,as a group of risk groups,has proven that it has certain rationality,compared with the low-risk group,the sleep quality,cognitive function of high-risk groups,and even the results of the specific work memory tasks and the intensity of brain activity are performed significantly,and the overall situation is highly consistent.Therefore,the screening basis for stop-bang for high-risk groups is supposed to be worth trying and doing further.