| Objective: To investigate the clinical efficacy and safety of hyperbaric oxygen combined with repetitive transcranial magnetic stimulation(r TMS)in reducing neurological function deficit,improving limb motor function and daily living ability in patients with motor dysfunction after cerebral infarction.To provide more effective treatment for patients with limb motor dysfunction after stroke.Methods: Seventy-eight patients who met the criteria of this study were selected strictly according to the inclusion criteria and exclusion criteria,and randomly divided into control group and treatment group with,39 patients in each group.All patients received routine rehabilitation treatment.The patients in the control group were treated with hyperbaric oxygen,and the patients in the treatment group were treated with hyperbaric oxygen and low frequency repetitive transcranial magnetism.Hyperbaric oxygen therapy lasted 115 min each time,once/day,6 times/week,for 3 consecutive weeks.On the basis of the control group,the treatment group was given the primary motor cortex(M1)1Hz r TMS treatment,20 min/time,once/day,90%RMT,6 times/week,for 3 consecutive weeks.Before and after treatment,the National Institutes of Health Stroke Scale(NIHSS),Fugl-Meyer assessment(FMA)and Modified Barthel Index Scale(MBI)were used to evaluate the degree of neurological impairment,the motor function of the upper and lower limbs of the affected side and the ability of daily living,respectively.The data will be obtained for statistical analysis.Results: During the whole clinical study,no cases were removed or detached.(1)The effects of the NIHSS Scale: Before treatment,there was no significant difference in NIHSS scores(8.26±2.24、8.54±2.16)between the control group and the treatment group(P > 0.05).After 3 weeks of treatment,the NIHSS scores of both(6.18±2.05、5.13±1.85)were lower than those before treatment,and the extent of decrease in the treatment group was significantly greater than that of the control group(P<0.05).(2)The effects of upper limb FMA scale: Before treatment,there was no significant difference in upper limb FMA scores(26.90±6.72、24.92±8.07)between the control group and the treatment group(P>0.05).After 3 weeks of treatment,the upper limb FMA scores of both(34.13±5.42、38.08±8.10)were higher than those before treatment,and the extent of increase in the treatment group was significantly greater than that of the control group(P<0.05).(3)The effects of lower limb FMA scale: Before treatment,there was no significant difference in lower limb FMA scores(12.36±5.18、12.23±4.64)between the control group and the treatment group(P>0.05).After 3 weeks of treatment,the lower limb FMA scores of both(16.18±4.65、18.54±4.70)were higher than those before treatment,and the extent of increase in the treatment group was significantly greater than that of the control group(P<0.05).(4)The effects of MBI scale: Before treatment,there was no significant difference in MBI scores(41.69±7.82、40.51±8.76)between the control group and the treatment group(P>0.05).After 3 weeks of treatment,the MBI scores of both(49.41±10.78、54.46±10.30)were higher than those before treatment,and the extent of increase in the treatment group was significantly greater than that of the control group(P<0.05).Conclusion:(1)Both the control group and the treatment group had significant effects on improving the neurological function,motor function and daily living ability of the patients with motor dysfunction after cerebral infarction.(2)The treatment group was significantly better than the control group in reducing NIHSS score,improving FMA score and MBI score,indicating that HBO combined with r TMS can further improve the neurological function,promote the recovery of motor function and improve the ability of daily living activities of patients after cerebral infarction. |
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