| ObjectiveTo observe the distribution of TCM syndrome types in patients with type 2 diabetes and dyslipidemia,study the relationship and differences between TCM syndrome types and physical and chemical indicators in the distribution of syndrome types,look for risk factors for TCM syndrome type distribution,and establish correlations between TCM syndrome types and risk factors related indicators Combined discriminant model.MethodsA total of 248 inpatients were collected from February 2020 to December 2020 in the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine.The researchers used a unified survey scale to collect the clinical data of the study subjects,Including general information,four-diagnosis information of traditional Chinese medicine and clinical physical and chemical indicators.The data processing uses Excel to establish a database,and SPSS 25.0is used for statistical analysis.General information is descriptive statistics.Differences in physical and chemical indicators between syndrome types are analyzed by analysis of variance and non-parametric tests.The analysis of risk factors affecting the distribution of TCM syndromes uses disordered multi-class logistic regression analysis.The discriminant model was established using Fisher discriminant analysis.Results1.The distribution of TCM syndromes in type 2 diabetes and dyslipidemia is as follows: qi and yin deficiency syndrome> damp-heat internal accumulation syndrome >liver-kidney yin deficiency syndrome> lung and stomach heat syndrome>spleen and kidney yang deficiency syndrome.2.In general data,sex,age,course of disease,body mass index(BMI),smoking history,drinking history and common complications were significantly different in the distribution of TCM syndrome types(P<0.05).Males have the syndrome of internal accumulation of dampheat,followed by the syndrome of deficiency of both qi and yin and the syndrome of excessive heat in the lung and stomach.Females have the syndrome of deficiency of both qi and yin,followed by the syndrome of deficiency of liver and kidney yin and internal accumulation of damp-heat.Age showed the distribution trend of lung and stomach heat syndrome >damp-heat internal accumulation syndrome>qi yin deficiency syndrome>spleen and kidney yang deficiency syndrome>liver and kidney yin deficiency syndrome distribution trend.The course of the disease is the lung and stomach heat syndrome>damp-heat internal accumulation syndrome>qi yin deficiency syndrome>liver kidney yin deficiency syndrome>spleen and kidney yang deficiency syndrome distribution trend.The distribution of BMI is as follows:damp-heat internal accumulation syndrome>lung and stomach heat syndrome>liver and kidney yin deficiency syndrome>spleen and kidney yang deficiency syndrome>qi yin deficiency syndrome.Patients with a history of smoking the syndrome of internal accumulation of dampheat is the main one,followed by the syndrome of deficiency of both qi and yin.Patients with a history of drinking have the syndrome of internal accumulation of damp-heat,followed by the syndrome of deficiency of both qi and yin.Patients with peripheral vascular disease have the syndrome of deficiency of both qi and yin.The syndrome of internal accumulation of dampheat and the syndrome of liver and kidney yin deficiency are the second;the patients with peripheral neuropathy have the syndrome of deficiency of both qi and yin,followed by the syndrome of deficiency of liver and kidney yin and the syndrome of internal accumulation of damp-heat;the patients with retinopathy have the deficiency of liver and kidney yin syndrome is the main syndrome,followed by spleen and kidney yang deficiency syndrome and qi and yin deficiency syndrome;patients with diabetic nephropathy have spleen and kidney yang deficiency syndrome as the main syndrome,followed by liver and kidney yin deficiency syndrome and qi and yin deficiency syndrome.3.Physical and chemical indicators:(1)Glucose indicators: Fasting plasma glucose(FPG)is statistically significant in the distribution of syndrome types,but no significant differences between groups are found after pairwise comparison.(2)Blood lipid indicators: Triglyceride(TG)levels in damp-heat internal accumulation syndrome significantly higher than the deficiency of both qi and yin,P<0.05;the level of low-density lipoprotein cholesterol(LDL-C)in the syndrome of damp-heat internal accumulation was significantly higher than that of the deficiency of both qi and yin and liver and kidney yin deficiency,both P<0.05;the high-density lipoprotein cholesterol(HDL-C)level of internal accumulation syndrome was significantly lower than that of liver and kidney yin deficiency syndrome,P<0.05.(3)Prethrombotic state index: the fibrinogen(FIB)level of the lung and stomach fever group was significantly lower the level of FIB in the syndrome of deficiency of both qi and yin and spleen and kidney yang,damp-heat internal accumulation syndrome was significantly lower than that of spleen and kidney yang deficiency syndrome,P<0.05;the level of d-dimer in the syndrome of pulmonary and stomach heat was significantly lower than that of qi yin both deficiency syndrome and spleen and kidney yang deficiency syndrome,P<0.05.(4)Disease prediction index: the blood homocysteine(Hcy)level of the spleen and kidney yang deficiency syndrome is significantly higher than that of the lung P<0.05 for both stomach heat syndrome and liver and kidney yin deficiency;the urine microalbumin(U-m ALB)level of spleen and kidney yang deficiency syndrome was significantly higher than the other four groups,and the U-m ALB level of liver and kidney yin deficiency was also significantly higher than the other 3 groups,P<0.05;the carotid artery intima-media thickness(IMT)of the lung and stomach heat syndrome is significantly lower than that of the qi and yin deficiency,liver and kidney yin deficiency,and spleen and kidney yang deficiency,P <0.05.4.The disordered multi-class logistic regression analysis showed that:(1)the syndrome of heat in the lungs and stomach and internal accumulation of damp-heat syndrome: age,course of disease,smoking history,history of diabetic nephropathy,LDL-C,HDL-C are the factors that affect the distribution of the syndrome types risk factors;(2)lung and stomach heat syndrome and qi and yin deficiency syndrome: course of disease,history of diabetic nephropathy,FPG are risk factors affecting the distribution of its syndrome types;(3)lung and stomach heat syndrome and liver and kidney yin deficiency syndrome : age,course of disease,history of diabetic nephropathy,and urine microalbumin are risk factors that affect the distribution of its syndrome types;(4)lung and stomach heat syndrome and spleen and kidney yang deficiency syndrome: age,drinking history,urine microalbumin are the risk factors affecting the distribution of syndrome types;(5)damp heat internal accumulation syndrome and qi-yin deficiency syndrome: smoking history,TG,LDL-C,HDL-C,IMT are risk factors that affect the distribution of syndrome types;(6)internal damp-heat syndrome and liver and kidney yin deficiency: LDL-C,HDL-C,and urine microalbumin are risk factors that affect the distribution of its syndrome types;(7)damp heat internal accumulation syndrome and spleen and kidney yang deficiency syndrome: drinking alcohol history and urine microalbumin are risk factors affecting the distribution of syndrome types;(8)qi and yin deficiency syndrome and liver and kidney yin deficiency syndrome: diabetic retinopathy history and urine microalbumin are risk factors affecting the distribution of syndrome types;(9)qi and yin deficiency syndrome and spleen kidney yang deficiency syndrome: drinking history and urine microalbumin are the risk factors affecting the distribution of syndrome types;(10)liver and kidney yin deficiency syndrome and spleen-kidney-yang deficiency syndrome: urine microalbumin is the influence risk factors for the distribution of syndrome types.Conclusions1.The distribution pattern of TCM syndromes of elderly patients with stable coronary heart disease presents a trend of qi and yin deficiency syndrome> damp heat syndrome>liver-kidney yin deficiency syndrome> lung and stomach heat syndrome>spleen and kidney yang deficiency syndrome.2.In this study,there were significant differences in the distribution of syndrome types in the general data among sex,age,course of disease,BMI,smoking history,drinking history and Common complications.3.Physical and chemical indexes of modern medicine: fasting plasma glucose,triglyceride,ldlc,hdl-c,fibrinogen,d-dimer,homocysteine,urine microalbumin and carotid intima-media thickness showed significant differences in the distribution of TCM syndromes.4.Age,course of disease,fasting plasma glucose,triglyceride,ldl-c,hdl-c,urine microalbumin and carotid intima-media thickness are risk factors affecting the distribution of TCM syndrome types. |
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