| Purpose1.Through literature research,evaluate the current status of the safety of traditional C hinese medicine in the treatment of coronary heart disease.2.Through systematic evaluation and Meta analysis of the effect of Chinese medicine for replenishing qi on heart rate variability in the treatment of coronary heart disease.3.Through retrospective research,evaluate the safety of Chinese medicine for replenis hing qi in the treatment of coronary heart disease.Method1.The first part of the literature research evaluates the safety degree of traditional Ch inese medicine in the treatment of coronary heart disease by searching the reports of adverse reactions in the treatment of coronary heart disease by Chinese medicine in re cent years and the literature of the safety evaluation system of Chinese medicine in th e treatment of coronary heart disease.2.The second part of the systematic review and meta-analysis was carried out accordi ng to the Cochrane practice manual,and included randomized controlled clinical trials that observed the effect of traditional Chinese medicine on heart rate variability in the treatment of coronary heart disease,and evaluated whether it increased HRV levels.3.The third part adopts a retrospective cohort study method to examine the patient’s age,gender,and disease status(coronary heart disease/ Non-coronary heart disease),di sease course,use of traditional Chinese medicine,and heart rate variability(HRV)indi cators are registered,summarized,and analyzed.Result1.The first part of the literature research results suggest that in the treatment of coro nary heart disease with traditional Chinese medicine,there are fewer reports of advers e reactions and higher safety.At present,in the traditional Chinese medicine safety ev aluation system for cardiovascular system damage,there is a lack of evaluation indicat ors that can detect and monitor arrhythmia and other serious cardiovascular adverse ev ents for early prediction.2.The results of the second part of the systematic review and Meta analysis suggest t hat traditional Chinese medicine combined with Western medicine is better than Wester n medicine alone in improving the levels of SDNN,SDANN,RMSSD,PNN50,LF,a nd HF.Chinese medicine can reduce arrhythmia and sudden cardiac death by increasin g HRV levels.And other serious cardiovascular adverse events to improve the safety of medication.3.The third part of the retrospective research results3.1 Compared with the HRV level of patients with coronary heart disease and non-cor onary heart disease patients,the HRV level of patients with coronary heart disease is lower than that of patients with non-coronary heart disease(p<0.05),and the HRV lev el of patients with coronary heart disease who have had the disease for more than 10years is less than 5 years,5-10 years of HRV level(p<0.05).3.2 The HRV level of patients who used Chinese medicine to treat coronary heart dis ease was higher than that of patients who did not use Chinese medicine to treat coro nary heart disease(p<0.05).3.3 There was no significant difference in HRV between patients with coronary heart disease who used Chinese medicine and those who did not use Chinese medicine for more than 10 years(p>0.05).Conclusion1.The first part of the literature research suggests that there are fewer reports of adv erse reactions in the treatment of coronary heart disease with Chinese medicine for re plenishing Qi,and the safety is higher.2.The second part of the Meta analysis results suggest that different formulations of Chinese medicines for the treatment of coronary heart disease can increase the HRV level of patients with coronary heart disease,so as to reduce the occurrence of cardio vascular adverse events and improve the safety of Chinese medicine in the treatment of coronary heart disease.3.The third part of the retrospective research results suggest that the reduction of H RV levels after coronary heart disease increases the risk of cardiovascular adverse eve nts such as arrhythmia and sudden cardiac death.The risk is higher after the course o f the disease exceeds 10 years.The use of Chinese medicine for replenishing qi can i ncrease the HRV level of patients with coronary heart disease and reduce the risk of adverse cardiovascular events.Early medication can increase the HRV level and benefi t patients more significantly.In the treatment of patients with coronary heart disease with a course of more than 10 years in traditional Chinese medicine,the effect of si mply replenishing qi in reducing the risk of cardiovascular adverse events is not signif icant.The long-term comprehensive treatment method of replenishing qi is needed,and combining warming yang,promoting blood circulation,and diuresis.treatment. |
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