Effect Of Shuxuening Injection On Total Ischemic Burden In Patients With Unstable Angina (Heart-Blood Stasis Pattern)

Objective: To observe the effects of Shuxuening injection on the times of angina attacks,total ischemia burden,TCM syndrome scores,GRACE risk level,liver and kidney function and coagulation function in patients with unstable angina(heart-blood stasis pattern)of coronary heart disease,so as to confirm the efficacy and safety of Shuxuening injection.Methods: In this study,48 patients with unstable angina(heart-blood stasis pattern)were selected from the First and Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from May 2019 to January2021.All these patients’ ages were between 30 and 75,and were randomly divided into 2 groups,including 36 cases in the trail group and 12 cases in the control group.The trail group was treated with Shuxuening injection on the basis of conventional western medicine treatment,and the control group was treated with conventional western medicine and placebo.Changes in the times of angina attacks,total ischemia burden,TCM syndrome scores and GRACE risk level were recorded and analyzed.At the same time,liver and kidney function and coagulation function of the patients were observed as safety indicators.The obtained data were analyzed by SPSS25.0.Results:1.Comparison of the times of angina attack: After treatment,The reduction degree of angina attack times in the trail group was higher than that in the control group(p< 0.05);2.Comparison of total ischemia burden: After treatment,TIB in the trial group was decreased(p< 0.05);There was no significant difference of TIB of the control group(p> 0.05));The reduction degree of TIB in the trail group was higher than that in the control group,TIB of the trail and control group after treatment was different(p< 0.05);The therapeutic effective rate difference was statistical significant between the two group(p< 0.05);3.Comparison of TCM syndrome scores: After treatment,the scores of TCM syndrome in trail group were decreased(p < 0.05);there was no significant difference of TCM syndrome scores of the control group((p >0.05));The reduction degree of TCM syndrome scores in the trail group was higher than that in the control group,and the difference was statistically significant(p < 0.05);The effective rate was compared between the two groups after treatment,and the difference was statistically significant(p<0.05);4.Comparison of GRACE risk level: After treatment,the GRACE risk level distribution between the two groups was compared,and the difference was statistically significant(p< 0.05);5.Safety indicators: Both in the trial and control group,there were no difference between liver and kidney function and coagulation function in both groups(p> 0.05).Conclusions:1.Shuxuening injection can reduce the times of angina attack in patients with unstable angina;2.Shuxuening injection can reduce the total ischemic burden in patients with unstable angina;3.Shuxuening injection can reduce the TCM syndrome scores of patients with unstable angina and relieve the clinical symptoms of patients;4.Shuxuening injection can reduce the proportion of the intermediate risk stratification in the GRACE risk grade of discharged patients with unstable angina;5.Shuxuening injection had no adverse effect on liver and kidney function and coagulation function.