| BackgroundOne of the most common causes of aphasia is stroke.Patients with post-stroke aphasia(PSA)often have language understanding and expression barriers,which seriously affect their daily communication.Non-invasive brain stimulation technology for the treatment of aphasia is currently a hot spot in the research on rehabilitation of aphasia,and transcranial direct current stimulation(t DCS)is one of the most commonly used methods.However,because the treatment parameters,such as site,intensity,time are controversial,the treatment effects are various.In addition,patients with PSA often have non-language-based cognitive dysfunction.So,it is necessary to explore the effects of t DCS on the auditory comprehension,expression and non-language-based cognitive functions,and analyze the relationships between them.What is more,it is of positive significance for the parameters selection of t DCS and the formulation of rehabilitation treatment programs for patients with PSA.Objectives1.Observe the effect of t DCS treatment in the left posterior superior temporal gyrus on the oral comprehension and expression disorder of patients with post-stroke aphasia.2.Analyze the correlation between non-language-based cognitive function and the improvement of language function in patients with post-stroke aphasia.MethodsThirty patients with PSA who met the selection criteria were randomly divided into the experimental group and the control group.Two groups of patients received the same drug treatment,the experimental group received the anode t DCS true stimulation(2m A,20 minutes)in the left posterior superior temporal gyrus,while the control group received the anode t DCS sham stimulation(2m A,30 seconds)in the same area.Both groups received conventional speech therapy(30 minutes)at the same time as the t DCS stimulation,one time a day,10 times in total within 2 weeks.Before and after treatment,both groups of patients underwent the Aphasia Battery of Chinese scale(ABC),Token test,auditory word-picture matching and picture-naming test in the Psycholinguistic Assessment in Chinese Aphasia(PACA),and the Non-Language-based Cognitive Assessment(NLCA)evaluation.The improvement of language comprehension and expression ability and non-language-based cognitive function of patients in the two groups were compared,and the correlation between non-language-based cognitive function and improvement of language function was analyzed.Results1.Language function(ABC): Intra-group comparison: After treatment,the total score and the sub-items scores of conversation,comprehension,retelling,naming,and reading in ABC scale in both groups were significantly different from those before treatment(P <0.05);Comparison between groups: After treatment,there was no significant difference in the improvement in the total score and the sub-items scores of conversation,comprehension,retelling,naming,and reading in the experimental group(P > 0.05).2.Language comprehension items: Intra-group comparison: After treatment,the two groups of patients have improved the auditory word-picture matching(total score,high-frequency and low-frequency words,and reaction time)and the Token Test score,and the difference is statistically significant(P < 0.05).Comparison between groups:After treatment,there was no significant difference in the improvement of the auditory word-picture matching(total score,high frequency words and low frequency words)and Token Test score between the experimental group and the control group(P > 0.05).After treatment,the improvement degree of the experimental group was better than that of the control group in the reaction time of listening to the auditory word-picture matching,the difference was statistically significant(P < 0.05).3.Specific language expression: Intra-group comparison: the picture naming(total score,high frequency,low frequency words and reaction time)after treatment in both groups was improved compared with those before treatment,and the difference was statistically significant(P < 0.05).Comparison between groups: After treatment,the correct rate of view naming(total score,high-frequency words and low-frequency words)in the experimental group was not significant different from that of the control group(P >0.05);The improvement degree of the experiment group was better than that of the control group,and the difference was statistically significant(P < 0.05).4.Non-language-based cognitive function: Intra-group comparison: the total score and the sub-items scores of memory,logical reasoning,visual space and attention in the experimental group were improved after treatment,the difference was statistically significant(P < 0.05);the total score and the sub-items scores of memory,logical reasoning and visual space in the control group were improved after treatment,the difference was statistically significant(P < 0.05);Comparison between groups: After treatment,the improvement degree in the attention sub-item of the experimental group was statistically significant compared with that of the control group(P < 0.05);the total score and the sub-items of memory,logical reasoning,visual space,and executive power were improved compared with the control group.The difference was not statistically significant(P > 0.05).Correlation analysis: Correlation analysis: The total score of non-language-based cognitive function and the sub-item score of logical reasoning were moderately positively correlated with the improvement of language function,and the correlation coefficient γ value was 0.535 and 0.509,respectively(P < 0.05).Conclusion1.Both conventional language training and transcranial direct current stimulation can improve the language comprehension and expression ability of patients with post-stroke aphasia.2.Compared with conventional language training,transcranial direct current stimulation can significantly shorten the reaction time of patients with post-stroke aphasia.3.Non-language-based cognitive function is positively correlated with the improvement of language function in patients with post-stroke aphasia. |
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