Correlation Between Inflammatory Markers Such As Neutrophil-lymphocyte Ratio And Prognosis In Patients With Hypertensive Intracerebral Hemorrhage

[Background]Spontaneous intracerebral hemorrhage(SICH),the second most common subtype of all stroke classifications,is a critical illness in which patients are often left with varying degrees of disability or even death.Hypertensive intracerebral hemorrhage(HICH),as the most common type of SICH,is also characterized by high mortality and disability rate.Numerous available research data suggest that the inflammatory response may be involved in the process of secondary brain injury after HICH,and is an important factor affecting the prognosis of HICH.In this study,we recorded the prognosis of HICH patients,and studied and analyzed the correlation between some inflammatory markers in the peripheral blood of HICH patients and the prognosis of HICH patients to provide a relevant basis for clinical decision-making.[Objective]To study and discuss the correlation between inflammatory markers such as peripheral blood neutrophil-lymphocyte ratio and the prognosis of HICH patients.[Method]In this study,187 patients with hypertensive intracerebral hemorrhage admitted to the Department of Cerebrovascular Disease,the Sixth Affiliated Hospital of Guangzhou Medical University from November 2018 to December 2020 were selected and followed up for 90 days.The internationally accepted Modified Ranks Score(MRS)prognostic score table was used to score the hypertensive intracerebral hemorrhage patients at 90 days after onset.The inflammatory factors affecting the prognosis of the patients were found and analyzed through the collected clinical baseline information,imaging data,laboratory blood draw data and other relevant data.[Results]A total of 187 patients diagnosed with HICH and hospitalized in the Sixth Affiliated Hospital of Guangzhou Medical University between November 2018 and December 2020 were included in this study.In the good-poor prognosis group,the area under the curve(AUC)of subjects with white blood cell count,neutrophil count,neutrophil-lymphocyte ratio(NLR),and lymphocyte-monocyte ratio(LMR)was greater than 0.7,with good predictive ability.Multivariate binary logistics analysis adjusted for surgery,bleeding volume,ventricular rupture,systolic blood pressure on admission,and Glasgow coma scale(GCS)score on admission as confounders yielded independent risk factors for high white blood cell count,high grade granulocyte count,high monocyte count,high NLR,high platelet-lymphocyte ratio(PLR),low lymphocyte count,and low LMR(P value < 0.05).In the death-survival group,the AUC of white blood cell count,neutrophil count,lymphocyte count,NLR,and LMR were greater than 0.7,with good predictive ability.Multivariate binary logistics analysis adjusted for surgery,bleeding volume,ventricular rupture,systolic blood pressure on admission,and GCS score on admission as confounders yielded independent risk factors for high white blood cell count,high grade granulocyte count,high monocyte count,high NLR,low lymphocyte count,and low LMR(P value <0.05).[Conclusion]1.White blood cell count,neutrophil count,NLR,and LMR had a good predictive ability for poor 90-day prognosis in HICH patients.2.White blood cell count,neutrophil count,lymphocyte count,NLR,and LMR had a good predictive ability for 90-day mortality outcome in HICH patients.3.Independent risk factors for poor 90-day prognosis in HICH patients were high white blood cell count,high grade granulocyte count,high monocyte count,high NLR,high PLR,low lymphocyte count,and low LMR.4.Independent risk factors for 90-day mortality outcome in HICH patients are high white blood cell count,high grade granulocyte count,high NLR,low lymphocyte count,low LMR.