Impact Of Activated Carbon Nanoparticle For Postoperative Short-term Efficacy Of Papillary Thyroid Carcinoma

Objective:To explore the application of carbon nanoparticle(CNP)during total thyroidectomy for papillary carcinoma,especially for parathyroid preservation,central neck dissection and postoperative serum thyroglobulin(Tg).Methods:228 patients were recruited retrospectively among those who performed total thyroidectomy and central neck dissection during January 2017 to June 2019.127 of them receiving injection of CNP intraoperatively were defined as CNP group while others were control group.Postoperative day 1 calcium and PTH,whether parathyroid gland inadvertently removed,number of central lymph nodes(LNs)resected,rate of metastasis and postoperative 1 month Tg were compared between two groups.Data of inadvertently removed parathyroid gland and yield of lymph nodes retrieved were collected on the basis of postoperative histology.Results:Postoperative day 1 calcium of CNP group and control group were 2.05mmol/L and 2.05mmol/L respectively,which demonstrated no significance(P=0.870).Postoperative day 1 PTH of CNP group was significantly lower than that of control group(13.9pg/m L vs.17.4pg/m L,P=0.039).Post-6 month hypoparathyroidism rate of the two groups were 7.1% and 5.0% respectively,which showed no significance(P=0.505).Amount of central LNs retrieved from CNP group and control group were 10.3 and 9.5 respectively.No significance could be discovered between them(P=0.601).Neither did significance between LNs involved of two groups,which was4.4 and 4.5 respectively(P=0.588).However,metastatic rate of black-dyed LNs was significantly lower than that of undyed(26.5%vs 52.9%,P=0.000).In terms of postoperative Tg level,CNP group was significantly higher than control group(4.26ng/m L vs 0.75ng/m L,P=0.025).Conclusion:The present study indicated that intraoperative using of carbon nanoparticles neither significantly increased the yield of lymph nodes retrieved in the central compartment nor help preserving parathyroid function.The metastatic rate of black-dyed LNs is lower than that of undyed.CNP would not be benefit for improvement of postoperative short-term oncologic outcomes among patients with papillary thyroid carcinoma.