Clinical Value Analysis Of Positive Results Of Fecal Occult Blood Test In Health Check-up Participants

Objective To explore the clinical value of positive results of fecal occult blood in health check-up participants in the early screening of colorectal cancer and precancerous lesions.Methods The subjects were selected from January 1,2017 to December 31,2019 in the Physical Examination Center of the Affiliated Hospital of Inner Mongolia Medical University.The subjects were the healthy individuals who chose quantitative immunochemical fecal occult blood test,interference factors were excluded,combined with the results of electronic colonoscopy of positive patients,analyze the positive rate of quantitative fecal immunochemical test,colonoscopy compliance rate,pathological results in different genders and age groups and occult blood levels of different lesions.Results A total of 37 474 cases of healthy individuals who chose quantitative immunochemical fecal occult blood test in the Health Check-up Center of our hospital in 3years.There were 23 271 males,accounting for 62.10%,and 14 203 females,accounting for37.9%.2 008 cases were detected as positive,the positive rate was 5.36%,of which 1 285 were males(64.00%),the positive rate was 5.52%,and 723 were females(36.00%),the positive rate was 5.09%.The positive rate of males was higher than that of females,and the difference was not statistically significant(χ~2=3.237,P=0.072),the positive rate increased with age,and the difference was statistically significant(χ~2=154.506,P=0.000).Among the population with positive fecal occult blood,416 patients participated in colonoscopy,the compliance rate of colonoscopy was 20.72%,the compliance rate of colonoscopy was 20.72%,275 cases(66.11%)were male,the compliance rate of colonoscopy was 21.40%,and the compliance rate of female 141 cases(33.89%)was 19.50%.There is no statistically significant difference in the compliance rate of male enteroscopy was higher than that of female(χ~2=1.016,P=0.314).among different age groups,the compliance rate of colonoscopy was the highest in the age group of 45-75 years,and the compliance rate of colonoscopy in the age group >75 was the lowest,and the difference was statistically significant(χ~2=8.983,P=0.03).Colonoscopy revealed 316 cases of intestinal lesions of varying degrees,with a total lesion detection rate of 75.96%.A total of 14 cases of colorectal cancer were detected,with a detection rate of 3.37%,and 212 cases of colorectal polyps,with a detection rate of 50.96%,including adenomas.There were 88 cases of sexual polyps,124 cases of non-adenomatous polyps,26 cases of enteritis,10 cases of ulcerative colitis,41 cases of hemorrhoids,and 13 cases of other diseases(colon melanosis,vascular abnormalities,diverticula,etc.).The difference in the detection rate of total lesions and adenomatous polyps between different genders was statistically significant(P<0.05 in all),the detection rate of men was higher than that of women,and the difference in the detection rates of colorectal cancer and non-adenomatous polyps was not statistically significant(P>0.05 in all).The detection rates of total lesions,adenomatous polyps,and non-adenomatous polyps among different age groups are statistically different(P<0.05 in all),the detection rate increased with age,and there was no statistically significant difference in the detection rate of colorectal cancer(P>0.05).The detection level of fecal occult blood is different for different pathological types.The level of fecal occult blood in colorectal cancer was higher than that of adenomatous polyps,and the difference was statistically significant(P<0.05).There was no statistically significant difference in fecal occult blood levels between adenomatous polyps and non-adenomatous polyps(P>0.05).Conclusion Fecal occult blood test is an ideal non-invasive test for early screening of colorectal cancer and precancerous lesions in health check-up participants.The compliance is relatively high.Colonoscopy after identifying high-risk groups can significantly increase the detection rate of lesions.It has important application value for reducing the incidence and mortality of colorectal cancer.