A Medical Research On Clinical Feature Of Parkinson’s Disease With Rapid Eye Movement Sleep Behavior Disorder

Objective: Parkinson’s disease(PD)is a common neurodegenerative disease among the elderly,which seriously affects their health and quality of life.Rapid Eye Movement sleep Behavior Disorder(RBD)has a high incidence in PD patients.To study the specific case characteristics of PD patients with RBD,so as to provide reference for the diagnosis,treatment and prognosis of such disease.Methods: The subjects of this study were Parkinson’s disease patients who visited Chifeng Hospital out-patient and in-patient.According to the RBD Screening Questionnaire(RBDSQ),whether the patient has RBD or not,is divided into 6 truncation value,which is divided into RBD group(RBDSQ≥6 points)and non-RBD group(RBDSQ < 6 points),compared the difference in baseline data between the two groups,The motor symptoms were assessed according to the part III of the Unified Parkinson’s Disease Rating Scale(UPDRS-III)and Hoehn&Yahr staging.Non-motor symptoms and the quality of life were assessed according to the Simple Mental Examination Scale(MMSE),Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD),and Parkinson’s Disease Quality of Life Questionnaire 39items(PDQ-39).And followed up continuously for more than 2 years.Compare the differentia of increased motor symptoms and cognitive decline between the two groups according to changes in the UPDRS-III and the MMSE.Results:In this study,120 patients were enrolled,all of whom were PD patients admitted to out-patient or in-patient department of neurology of Chifeng Hospital.There were 62(54.4%)patients in PD-RBD group and 52(45.6%)patients in PD-NRBD group.The man in PD-RBD group was obviously higher than that of PD-NRBD group(P < 0.05),there were no significant difference between the two groups in age,education level,course of disease,history of stroke,history of head trauma,history of general anesthesia,history of hypertension,history of diabetes,history of smoking,and history of alcohol consumption(P >0.05).Compared with the PD-NRBD group,the UPDRS-III scores of patients in the PD-RBD group were higher,as follows:[(38.87±15.01)points vs.(32.12±13.34)points,P<0.05];the proportion of Hoehn&Yahr staging was higher in middle and late stage,as follows:[(56.5%)vs.(36.5%),P<0.05];the MMSE score was lower,as follows:[(20.81±5.23)points vs.(23.81±4.14)points,P<0.05];HAMA scores higher,as follows: [(18.71±4.12)points vs.(12.42±5.65)points,P<0.05];HAMD scores higher,as follows:[(18.06±5.10)points vs.(12.04.12±6.23)points,P<0.05];the proportion of olfactory disorders,constipation,postural hypotension,hallucination,falls,freezing were higher(P<0.05),the proportion of rigid primary dyskinesia is higher(P<0.05),Levodopa is used more(P<0.05).Compared with the PD-NRBD group,the UPDRS-III score difference value(follow-up-enrollment)and MMSE score difference value(enrollment-follow-up)in the PD-RBD group were higher after 2 years of follow-up and at the time of enrollment,as follows: [(10.95±5.64)points vs.(8.90±3.16)points,P<0.05]、[(5.52±2.68)points vs.(4.54±2.27)points,P<0.05].Conclusion:PD patients with RBD have more serious motor symptom and non-motor symptoms.RBD can increase the aggravation of motor symptoms and cognitive decline in PD patients,as well as the anxiety and depression symptoms in patients.Therefore,it is necessary for us to develop an individual treatment plan for RBD patients,so as to reduce the incidence of poor prognosis in such patients.