Effect Of Allopurinol On Renal Disease Of Contrast Agent After Percutaneous Coronary Intervention In Patients With Coronary Heart Disease And Hyperuricemia

Objective: To investigate the effects of oral the allopurinol intervention,the hydration intervention and the allopurinol combined with hydration intervention on patients with coronary heart disease(CHD)and hyperuricemia(Hua)undergoing selective coronary angiography(CAG)or percutaneous coronary intervention(PCI).There is no significant difference in the preventive effect of contrast induced nephropathy(CIN)after PCI.Methods: 160 patients with coronary heart disease complicated with hyperuricemia who underwent CAG or PCI in our hospital from December 2019 to December 2020 were selected and randomly divided into the hydration group(n=40),the allopurinol group(n=40),the allopurinol+hydration group(n=40)and the control group(n=40).The speed and total amount of intravenous infusion can be adjusted individually according to the heart function,renal function,urine volume and body weight of the selected subjects;the patients in the allopurinol group were given 300 mg allopurinol tablets(100mg once,3 times a day)within 24 hours before PCI,while the patients in the allopurinol+hydration group were given hydration and oral allopurinol before PCI,and the control group was not given any intervention.The general condition of the patients was counted before operation.Routine examination was performed before operation.Serum creatinine(SCr)was detected before operation,24 hours and 48 hours after operation.Estimated glomerular filtration rate(e GFR)was estimated by CKD-EPI formula as the observation index.Results: there was no significant difference in baseline data among the four groups,which was comparable;SCr and e GFR were compared before operation,24 hours after operation and 48 hours after operation in the control group,while there was no significant difference in the allopurinol group and the allopurinol+hydration group before operation and 24 hours and 48 hours after operation,and there was significant difference in e GFR before operation and 48 hours after operation in the hydration group.There was no significant difference between the three groups in terms of SCr and e GFR before and after operation,but there was no significant difference between the three groups.There was no significant difference in SCR and e GFR between the three groups.There was no significant difference in SCr and e GFR between the three groups.The difference of e GFR and e GFR was statistically significant.No adverse drug reactions occurred during hospitalization,and no adverse events occurred during follow-up within half a year.Conclusion: 1.Preoperative hydration,allopurinol and hydration combined with allopurinol can effectively reduce the incidence of CIN in patients with coronary heart disease and hyperuricemia after CAG/PCI;2.There is no significant difference between allopurinol alone and hydration combined with allopurinol in the prevention of CIN in patients with coronary heart disease and hyperuricemia after CAG/PCI.The effect of hydration alone may be slightly worse than that of allopurinol alone and hydration combined with allopurinol.