Correlation Analysis Of Serum ApoA1 And BMI With The Occurrence And Development Of Non-alcoholic Fatty Liver Disease-related Hepatocellular Carcinoma

Purpose: Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the world.It is related to the occurrence and development of hepatocellular carcinoma(HCC).The clinical indicators of lipid metabolism,as the main monitoring indicators throughout the course of NAFLD,can be clearly reflected To find out the severity of NAFLD,this article aims to explore the correlation between the clinical indicators of lipid metabolism and the occurrence and development of non-alcoholic fatty liver disease-related hepatocellular carcinoma(NAFLD-HCC),and to provide meaningful clinical markers for NAFLD-HCC.Methods: A retrospective collection of 111 NAFLD-HCC patients who were hospitalized in our hospital from January 1,2015 to January 1,2020 and underwent therapeutic operations as the positive group,while 153 NAFLD patients were collected as the negative group,and all were determined Include the patient’s gender,age,height,weight,diabetes history,serum TC,TG,HDL-C,LDL-C,ApoA1,Apo B,FPG,ALT,AST,GGT,calculate the patient’s BMI and GGT/ALT,use The SPSS 24.0 statistical software performs statistical analysis on the clinical data of the positive group and the negative group to determine the difference in lipid metabolism between the two groups.It is speculated that it may have a certain significance in the occurrence of NAFLDHCC,where P<0.05 means The difference was statistically significant;the serum AFP of patients with NAFLD-HCC,post-tumor pathology report(including the presence or absence of microvascular invasion(MVI),tumor maximum diameter)and postoperative tumor-free survival were calculated,and the difference between different groups was calculated Tumor-free survival curve to analyze the relationship between lipid metabolism indicators and the prognosis of NAFLD-HCC patients;based on MVI being the most weighted prognostic risk factor,we divided into MVI group and MVIfree group based on postoperative pathological data,and SPSS 24.0 statistical software was used to analyze The clinical data of the MVI group and the non-MVI group were statistically analyzed to determine the correlation between lipid metabolism indicators and NAFLD-HCC combined with MVI,where P<0.05 indicates that the difference is statistically significant.Results: 1.Non-parametric chi-square analysis showed that age,gender,TG,ApoA1,GGT/ALT,AST/ALT,BMI were statistically significant between NAFLD and NAFLDHCC two groups;2.Long-Rank single factor analysis It shows that age,GGT/ALT,ApoA1,BMI,AFP,tumor maximum diameter,and MVI are risk factors for postoperative tumor-free survival in patients with NAFLD-HCC.Multivariate analysis of Cox proportional hazards regression model shows that ApoA1,BMI,MVI and tumor are the largest Path is an independent risk factor for postoperative tumor-free survival in NAFLD-HCC patients;3.Non-parametric chi-square analysis shows that age,TG,ApoA1,GGT/ALT,AST/ALT,and BMI are between the MVI group and the no MVI group.Statistical difference,multivariate Logistic regression model analysis showed that ApoA1 and BMI are independent risk factors for NAFLD-HCC combined with MVI.Conclusion: Serum TG,ApoA1,GGT/ALT,AST/ALT and BMI are statistically different between NAFLD and NAFLD-HCC,which may be related to the occurrence of NAFLD-HCC;secondly,serum ApoA1 and BMI are not related to NAFLD patients after surgery.Tumor survival is related and can be used as an independent risk factor for its recurrence;finally,serum TG,ApoA1,GGT/ALT,AST/ALT and BMI are related to NAFLD-HCC combined with MVI,and ApoA1 and BMI can be used as NAFLDHCC combined with MVI In summary,it can be concluded that ApoA1 and BMI may be related to the occurrence and development of NAFLD-HCC.Regular monitoring of ApoA1 and BMI has certain clinical guiding significance for the occurrence and development of NAFLD-HCC.