The Correlation Study Of Serum Uric Acid Level With Gensini Score And Short-term Prognosis In Patients With Coronary Heart Disease

Objective: The objective of this study was to determine and compare the serum uric acid(SUA)levels in patients with coronary heart disease(CHD)and without CHD,explore the correlation between serum uric acid level and Gensini score which reflects the severity of coronary artery disease in patients with CHD,and assess the predictive value of uric acid on major adverse cardiovascular and cerebrovascular events(MACE)in patients with CHD within one year.Methods: A total of 137 suspected CHD patients hospitalized in our hospital were selected.According to the results of coronary angiography,the patients with at least one coronary artery stenosis ≥50% were included in the CHD group(n=85,58 males and 27 females),and the patients with coronary artery stenosis < 50% or without coronary artery stenosis were included in the non-CHD group(n=52,24 males and 28 females).Patients with CHD discharged from hospital were followed up for one year,and the occurrence of MACCE was recorded.General data between the two groups were compared.The presence and severity of CHD were evaluated by coronary angiography.The severity of coronary artery lesions was evaluated by Gensini score.Statistical analysis was performed to evaluate the relationship between SUA level and the severity of CHD coronary disease.Spearsman correlation coefficient and Cox regression analysis were used to evaluate the correlation between serum uric acid level and short-term prognosis of patients.Results:1.Two groups of patients,in gender,age,BMI,smoking,drinking,hypertension,diabetes,stroke,white blood cell count,neutrophils absolute value,the monocyte absolute value,blood sugar,triglyceride,hypersensitive c-reactive protein,troponin I,UA,ejection fraction,statistically significant difference(P < 0.05);The uric acid value of female patients with CHD was337.18±90.62,and that of female patients without CHD was 268.93±68.29,and the difference was statistically significant(P < 0.05).2.Spearman correlation analysis showed that gender,body weight,age and BMI were correlated with serum uric acid level in CHD patients.The number of disaffected vessels,age and troponin I were correlated with the severity of CHD patients.The difference was statistically significant(P <0.05).3.One-year follow-up of patients with CHD after discharge revealed that the survival time of the group without hyperuricemia(10.31)was significantly higher than that of the group with hyperuricemia(7.19)(P < 0.05),and the Log Rank(Mantel-Cox)survival curve indicated that the incidence of MACCE was higher in patients with hyperuricemia(P < 0.05).Conclusion:Uric acid is a risk factor for coronary heart disease,and this effect is more evidently reflected in women.Coronary heart disease patients with hyperuricemia have poor short-term prognosis and more postoperative complications.