A Meta-analysis On Efficacy And Safety Of Pramipexole For Parkinson’s Disease

Objective: To systematically evaluate the efficacy and safety of pramipexole(PPX)compared with placebo in the treatment of Parkinson’s disease(PD).Methods:All pramipexole related randomized controlled trial(RCT)for the treatment of PD and related literature references were searched by the literature databases including PubMed,EMBASE,Cochrane Library,CNKI,Wanfang Data,VIP,CBMdise from the origination dates to December 31,2020.The Cochrane Risk Assessment for Bias was used for literature quality evaluation.According to the inclusion and exclusion criteria,two researchers independently completed literature screening,literature quality assessment,data extraction and cross-check.Meta-analysis of efficacy indexes and safety indexes was performed using Rev Man5.3 software.Heterogeneity was evaluated by I~2 value.We ighted mean difference(WMD)was used for measurement data,all effe ct sizes were represented by 95% confidence interval(CI),the incidence of adverse reactions was represented by odds ratio(OR)and 95%CI,and test level was set at 0.05.Results:A total of 10 RCTs were included in this study,involving 2455 patients.Results of Meta analysis showed that: a)Efficacy: Pramipexole total curative effect is superior to placebo for the treatment of PD,statistically significant differences in [WMD = 10.9208,95%CI(6.5439,15.2977),P < 0.0001],in the daily life quality improvement is better than that ofthe placebo group,the difference is statistically significant [WMD = 2.1998,95%CI(1.3803,3.0193),P < 0.0001],and motor function improvedbetter than that of the placebo group,difference has statistical significance,[WMD = 6.3836,95%CI(4.3905,8.3767).P <0.0001).b)Adverse Reaction Occurrence: adr pramipexole treatment group hallucinations,drowsiness,insomnia,confusion,fatigue,peripheral edema,constipation,nausea,move disease incidence is higher than the placebo group,differences were statistically significant,pramipexoleg roup of dizziness,headache,high incidence of orthostatic hypotension compared with placebo,there was no statistically significant difference.Conclusions:Currently,limited evidence has shown that pramipexole is effective in the overall efficacy,quality of daily life and motor function of Parkinson’s disease,and there are also adverse reactions such as hallucination,nausea,drowsiness,insomnia and dyskinesia.This study has certain limitations and needs to be further explored by more high-quality RCT studies.