Study On The Correlation Between Serum Vascular Endothelial Cell Cadherin(VE-cadherin) Level And Acute Ischemic Cerebrovascular Disease

Objective:1.To explore the relationship between serum vascular endothelial cell cadherin(VE-cadherin)and acute cerebral infarction(ACI)and transient ischemic attack(TIA),and whether there is a correlation between serum VE-cadherin and related blood indicators.2.Whether the serum VE-cadherin level of acute cerebral infarction is different from TOAST classification,OSCP classification,whether there is a correlation with NIHSS score.Methods: A total of 167 patients with acute ischemic cerebral infarction who met the criteria for inclusion and discharge in the Department of Neurology of the Second Hospital of Hebei Medical University from September 2018 to December 2019 were included.Divided into cerebral infarction group and TIA group.Collect and record complete information of all subjects including general information,related medical history,DWI and MRA imaging data,and collect fasting venous blood samples of all subjects,and detect serum VE-cadherin and homocysteine,Total cholesterol,triglycerides and other indicators.The indicators of the two groups of patients were statistically analyzed to find independent risk factors and linear correlations of serum VE-cadherin levels in patients with ischemic cerebrovascular disease.Results: The serum VE-cadherin level in the CI group was higher than that in the TIA group(β=32.4,95%CI:-7.5,72.4,P=0.1132).In the CI group,the serum VE-cadherin levels of patients with a history of hypertension or diabetes were higher than that of those without hypertension or diabetes,and the difference was statistically significant(P<0.05);In TOAST classification,serum VE-cadherin levels of patients with ischemic stroke of Stroke of other undetermined etiology were higher than those of TIA patients,and the difference between the two groups was statistically significant(β=166.8,P<0.05).Among CI patients,patients with OSCP classification PACI(partial anterior circulation infarction)had higher serum VE-cadherin levels than TIA patients,and the trend was statistically significant(β=50.4,P<0.05).There was no statistical difference in the onset time according to the continuous variable and the effect value of the binary variable after truncation(P>0.05).There was no significant correlation between age,sex,history of hyperlipidemia,history of smoking,history of alcohol consumption and serum VE-cadherin in the TIA group and CI group(P>0.05).Serum VE-cadherin in patients with cerebral infarction had no significant correlation with NIHSS score and the infarction in the anterior and posterior circulation(P>0.05).Serum VE-cadherin changes with the trend of peripheral blood lymphocyte count,MPVLR and blood lipid indicators.Conclusions: The level of serum VE-cadherin in patients with ischemic cerebrovascular disease is closely related to the occurrence of infarction,history of hypertension,history of diabetes,history of smoking,TOAST classification,and OSCP classification.Serum VE-cadherin levels in patients with ischemic cerebrovascular disease are not closely related to the number of days of onset,age,sex,history of hyperlipidemia,drinking history,NIHSS score,and the location of the infarct in the anterior and posterior circulation.The related blood index and serum VE-cadherin curve fitting graph have clear trend changes.