Effect Of Bifico Combined With Cimetidine On Necrotizing Enterocolitis In Very Low Birth Weight Infants

Necrotizing enterocolitis(NECrotizing Enterrocolitis,NEC)is a serious gastrointestinal emergency,which often occurs in premature infants with a body weight of less than 1500g,and the smaller the gestational age,the higher the prevalence,and the mortality rate is as high as 10%to 15%.The intestinal tract of newborns is sterile when they are born,and external colonies will enter the intestinal cavity and colonize within a few hours after birth.However,because the digestive system is not yet fully developed and the presence of drug-resistant microorganisms in the neonatal intensive care unit,it is easy to cause intestinal tracts in preterm infants.Ectopic microorganisms cause related diseases.In recent years,studies have found that microecological preparations have a preventive and therapeutic effect on NEC in preterm infants,have anti-inflammatory,improve intestinal immune function,and can maintain the integrity of the mucosal barrier.H2 receptor antagonist can reduce gastric acid secretion,inhibit inflammatory reaction,regulate immunity and antiviral effect.This article explores the effect of microecological preparations on NEC in very low birth weight infants and the effects on serum procalcitonin(PCT)and C-reactive protein(CRP)levels in children and the effect on the course of disease and weight gain of childrenPURPOSE:To study the effect of peficon combined with cimetidine on premature infants with necrotizing enterocolitis(NEC)and its effect on procalcitonin(PCT)and C-reactive protein(CRP)and the course of disease and weight gain of children.METHOD:Select 92 cases of premature infants with necrotizing enterocolitis from June 2017 to December 2019 in our hospital as the research object,the inclusion criteria:meet the"Avery Nephrology"diagnostic criteria for necrotizing enterocolitis in premature infants:X-ray examination revealed dynamic intestinal obstruction,accompanied by significant gastric distension,excessive fluid retention in the body,disordered arrangement of the small intestine,and gas accumulation in the intestinal wall.Not delivered at full term,birth weight≤1500g.All children were divided into three groups according to random number table method,including blank control group(25 cases),test group 1(34 cases)and test group 2(33cases).Children in all the groups were given conventional treatment such as continuous gastrointestinal decompression,fasting,anti-infection,and parenteral nutrition support.After the vital signs were stable,feeding was started;children in the test group 1 were given peficon treatment on the basis of conventional treatment,0.5 g/time,3 times/d,patients in the test group 2 were given cimetidine intravenously,5 mg/kg,once/d on the basis of treatment in the control group.At the same time,children were given acid-base balance and electrolyte balance correction,parenteral nutrition support treatment and antibiotic treatment,and all the groups received treatment for 7 days.After the treatment,compare the effectiveness of the three groups of children.During the treatment,the disease course and body mass growth of the three groups of children were recorded.The levels of procalcitonin(PCT)and C-reactive protein(CRP)in the three groups of children were measured by double antibody sandwich method.SPSS 19.0 statistical software was used for statistical analysis of the test data.RESULT:There was no statistically significant difference between the general clinical data of the three groups of children in terms of gender composition,average gestational age,average birth weight,cesarean section,chorioamnionitis,prenatal hypoxia,artificial breastfeeding(P>0.05).Comparability.In the blank control group,8 cases(32.00%)were markedly effective,7 cases(28.00%)were effective,10 cases(40.00%)were ineffective,and the total effective rate was 60.00%;in test group 1,11 cases(33.33%)were markedly effective,10 cases(30.30%)were effective,12cases(36.36%)were ineffective,and the total effective rate was 63.64%.In the experimental group 2,16 cases(47.06%)were markedly effective,13 cases(38.24%)were effective,and 5cases(14.71%)were ineffective,and the total effective rate was 85.29%;the total effective rate of the two groups was higher than that of the blank control group,the difference was statistically significant(χ~2=4.148,P=0.417),and the observation group 2 was significantly higher than the experimental group 1.The duration of the disease was(8.7±1.5)d in the blank control group,(6.2±1.2)d in the experimental group 1 and(4.1±1.1)d in the experimental group 2,which was significantly shorter than that in the experimental group 1 and the blank control group(P<0.05).The average daily body weight of the experimental group 2 was(14.5±3.2)g,the average daily body weight of the experimental group 1 was(8.3±1.8)g,and that of the blank control group was(7.5±2.2)g.the average daily body weight growth of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the expression levels of PCT and CRP in experimental group 2 were(3.47±1.21)ng/ml and(7.53±3.25)mg/L;those in experimental group 1 were(4.15±1.36)ng/ml and(8.25±3.54)mg/L;those in the blank control group were(6.47±1.17)ng/ml and(11.53±2.25)mg/L,respectively The levels of CRP and CRP in experimental group2 were significantly lower than those in control group 1(P<0.05).CONCLUSION:The combined application of peficon and cimetidine can play a synergistic role,improve the inflammatory state of children,shorten the duration of disease,increase the weight of children,and thus improve the efficacy.