| Objectives To study prognosis and long-term outcome of induction therapy with clotrimazole,followed by an extended period of maintenance therapy for recurrent vulvovaginal candidiasis(RVVC)and Candida species.Methods A retrospective study was performed of RVVC women visited in Peking University Shenzhen Hospital Vaginitis Clinic during a 5-year period(August 2014 to August2019).Data included Candida species distribution,the treatment efficacy after clotrimazole maintenance therapy and after an extended period of maintenance therapy.Results The age range of patients was 32.75±6.68(21~46 years old)without HIV infection.Of 267 patients based on culture-confirmed RVVC were started on the clotrimazole(n=267 cases)regimen.Candida albicans was the predominant Candida species(236 strains,88.4%)followed by C.glabrata(22 strains,8.2 %)and other nonalbicans species(9 strains,3.4 %).The mycological cure rate after the induction therapy,after the induction course at the end of 6 months of maintenance therapy and recurrence rate within 6 months after completion of consolidation therapy was 82.0 %(219/267cases),72.6 %(159/219 cases)and 25.8.%(41/159 cases)in the clotrimazole regimen,respectively.The cure rate of induction therapy,the cure rate of maintenance therapy and the recurrence rate within 6 months after the completion of consolidation therapy caused by Candida albicans,C.glabrata and other non-albicans species were 85.2%(201/236 cases),74.6%(150/201 cases),24.7%(37/150 cases),50.0%(11/22cases),36.4(4/11 cases),25.0%(1/4 cases);and 77.78%(7/9 cases),71.4%(5/7 cases),60.0%(3/5 cases),respectively.No patients appeared serious side reaction when they were treated.In vitro drug sensitivity test was performed in 267 cases of RVVC.Non-albicans other than C.glabrataConclusions:Clotrimazole vaginal suppositories therapy was highly effective and safety in preventing RVVC symptoms.clotrimazole is sensitive to all kind of Candida 。... |
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