| Objective:Collect and sort out the clinical data of herpes zoster(HZ)hospitalized patients,such as age,gender,location of onset,disease severity score,length of stay and other clinical data,and summarize the general clinical characteristics of HZ hospitalized patients.Retrospectively analyze the number of T lymphocytes and cytokine concentration in the peripheral blood of HZ hospitalized patients,and explore the effects of age,underlying disease,and disease severity on the changes in the number of T lymphocytes and cytokine concentration of HZ hospitalized patients.Method:The study subjects were selected from 261 patients with HZ who were hospitalized in the First Hospital of Hebei Medical University from2019.07 to 2020.07.Collect and sort out the age,gender,location of disease,and other data of the research subjects,analyze and summarize the general clinical characteristics of HZ inpatients in our hospital.The patients were divided into a young group(18≤age<45 years old)and a middle-aged group(≥45 years old),and then divided into no basic disease group and basic disease group according to whether they were accompanied by underlying diseases.Through statistical analysis of the patient’s gender,age,underlying disease,location of disease,disease severity and length of stay in hospital,the influence of the above factors on the length of hospital stay was discussed.Grouping statistics of peripheral blood T lymphocyte subsets(including CD4~+T%,CD8~+T%and CD4~+T/CD8~+T),cytokine concentration(including TNF-α,IFN-γ,IL-2,IL-4,IL-6)to understand the changes in the patient’s immune status,compare the differences between the groups,and analyze the related factors that cause the differences.SPSS 26.0 statistical software was used for data analysis,and P<0.05 was considered as statistically significant.Result:The study found that:(1)Among the HZ inpatients in our hospital during the period 2019.07-2020.07,middle-aged and elderly patients accounted for 63%,young people accounted for 37%;males accounted for52.87%,and females accounted for 47.13%.In order of frequency,the incidence sites were chest and back(32.18%),head,face and neck(29.12%),waist and abdomen(19.92%),sacrococcygeal(13.79%)and other parts(4.98%).Severity of the disease:36 cases were mild with a disease score of4.560±0.652;207 cases were moderate with a disease score of 8.200±1.691;17 cases were severe with a disease score of 13.44±1.199.(2)Length of hospital stay:The average length of hospital stay for men and women was9.950±2.581 and 9.930±2.430,respectively,and the difference was not statistically significant(P>0.05);the average hospitalization for chest,back,head,face and neck,waist and abdomen,sacrum and other parts The days were 9.900±2.462,9.830±2.430,9.600±2.622,10.330±2.552,11.080±2.565,and there was no statistically significant difference in the average length of stay among patients with different disease sites(P>0.05);the average length of stay in middle-aged and elderly patients was 10.370±2.452 is longer than youth 8.770±2.282,and the average length of stay in the group with underlying disease is 10.920±2.489 longer than that in the group without underlying disease is 9.270±2.297.The length of stay in patients with moderate and severe disease severity is 9.970±2.211 and 14.280±,respectively1.674,all longer than mild patients 7.610±1.128,and the difference was statistically significant(P<0.05).Multi-factor analysis of the effects of age,underlying diseases,and disease severity on length of stay was performed,and the differences were statistically significant(P<0.05).(3)The number and ratio of T lymphocyte subsets:In the same age group,the CD4~+T%and CD4~+T/CD8~+T of the group with underlying disease are lower than the group without underlying disease,and the CD8~+T%is higher than that of the group without underlying disease.There are differences Statistically significant(P<0.05).In different age groups,the CD4~+T%and CD4~+T/CD8~+T of the middle-aged and elderly people without basic diseases were lower than the youth without basic diseases,and the CD8~+T%was higher than the youth without basic diseases,the difference was statistically significant(P<0.05);The CD4~+T/CD8~+T of the youth with underlying disease group was higher than that of the middle-aged and elderly patients with underlying disease,the difference was statistically significant(P<0.05),but the difference in CD4~+T%and CD8~+T%between the two groups was not statistically significant(P>0.05).According to the severity of the disease,patients were divided into mild,moderate,and recombinant.There was no statistically significant difference in CD4~+T%,CD8~+T%,and CD4~+T/CD8~+T among different groups(P>0.05).(4)Cytokine concentration:There was no statistically significant difference in the concentration of TNF-α,IFN-γ,IL-2,IL-4,and IL-6 in the same age group,between the group with no underlying disease and the group with underlying disease(P>0.05).In different age groups,the concentration of IFN-γ,IL-2,IL-4,and IL-6 in the youth without underlying disease group was higher than that in the middle-aged and elderly people without underlying disease group,and the difference was not statistically significant(P>0.05);youth with underlying disease The level of TNF-αin the group was higher than that of the middle-aged and elderly with underlying diseases,and the difference was statistically significant(P<0.05).There was no significant difference in TNF-αbetween the young and middle-aged and elderly without underlying diseases(P>0.05);There was no significant difference in the concentration of TNF-α,IFN-γ,IL-2,IL-4,and IL-6 between the disease severity groups(P>0.05).Conclusion:2019.07-2020.07 HZ inpatients in our hospital are mainly middle-aged and elderly patients,and there are more men than women.Age,underlying diseases,and disease severity are independent risk factors that affect the length of hospital stay.Inpatients with HZ may be affected by aging and underlying diseases,and the body’s CMI will be further reduced;the concentration of related cytokines will also change accordingly,but whether the concentration of cytokines is related to age and underlying diseases remains to be further studied. |
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