Study On The Correlation Between Serum C1q Tumor Necrosis Factor-related Protein 1 (CTRP1) Level And Insulin Resistance And Dyslipidemia In People With Different Glucose Metabolism

Objective Taking people with different glucose metabolism status as the research object,by detecting the level of serum C1 q tumor necrosis factor-related protein 1(CTRP1)and related clinical indicators,discussing the distribution of each indicator in the population with different characteristics,and analyzing CTRP1 with insulin resistance and blood lipids The correlation between abnormalities provides a basis for the prevention and treatment of diabetes and dyslipidemia.Methods From December 2019 to December 2020,a completely random sampling method was adopted to select people with different glucose metabolism statuses in the Physical Examination Center of the Second Affiliated Hospital of Ningxia Medical University,and group them according to different fasting blood glucose levels from low to high,respectively: Normal group(3.9mmol/L≤IFG<5.6 mmol/L),IFG-1 group(5.6mmol/L≤IFG<6.1 mmol/L),IFG-2 group(6.1mmol/L≤IFG<7.0 mmol/L))And T2 DM group(IFG≥7.0 mmol/L).Among them,the IFG-1 group,IFG-2 group and T2 DM group were used as the case group,and the normal group was used as the control group.Carry out general information collection,physical examination,laboratory examination and determination of serum CTRP1 level.SPSS 25.0 statistical software was used to perform t test,analysis of variance,Mann-Whitney U test and Kruskal-Wallis test on samples between two groups and multiple groups.Pearson linear correlation analysis was performed on the relationship between CTRP1 and insulin resistance and dyslipidemia.The influencing factors of T2 DM,prediabetes and dyslipidemia were analyzed by multivariate logistic regression analysis,and the diagnostic efficacy of CTRP1 was evaluated by ROC curve analysis.Results 1.The current distribution of CTRP1,FINS and blood lipid levels showed that as blood glucose levels gradually increased,CTRP1 showed a downward trend.The average values in the normal group,IFG-1 group,IFG-2 group and T2 DM group were(149.09±19.12),respectively.,(138.05±15.46),(116.76±18.40),(97.54±22.18)ng/ml.As the blood glucose level gradually increased,FINS showed an upward trend.The average values of the normal group,IFG-1 group,IFG-2 group and normal group were(5.97±0.51),(5.05±0.48),(6.05±0.48),respectively.),(6.74±0.53)m IU/L.The distribution of TG,HDL-C and LDL-C was different among the groups.The CTRP1,TC,and HDL-C of males were lower than females(tvalues were 2.195,2.298,5.497,respectively).The CTRP1,TC,and HDL-C of males were lower than those of females(t-values were 2.195,2.298,5.497,respectively).Male FINS and TG are higher than females(t=1.970,U=4.586).Except for the same CTRP1 and TG in different age groups,the other indicators are different.Among them,FINS,TC,HDL-C,LDL-C are different in different age groups(F values are9.637,5.259,2.870,3.368,respectively).The above differences are all statistically significant(P<0.05).2.Correlation analysis showed that CTRP1 and HOMA-β in the T2 DM group were negatively correlated.Both male and female CTRP1 were negatively correlated with HOMA-IR,and positively correlated with HOMA-β.CTRP1 of different ages was negatively correlated with HOMA-IR,and positively correlated with HOMA-β.CTRP1 was negatively correlated with TG in IFG-1 group,CTRP1 was negatively correlated with HDL-C in IFG-2group.Male and female CTRP1 is negatively correlated with TG,female CTRP1 is positively correlated with HDL-C,and female CTRP1 is positively correlated with LDL-C.CTRP1 was negatively correlated with TG in the 25~,35~,45~year-old group,CTRP1 was negatively correlated with TC in the 25~year-old group,and CTRP1 was negatively correlated with LDL-C in the 25~year-old group.The above differences were statistically significant(P All<0.05).3.Logistic regression analysis showed that women(OR=0.062),DBP(OR=0.946),BMI(OR=0.861),Cr(OR=0.912),CTRP1(OR=0.912)were negatively correlated with the occurrence of prediabetes(P< 0.05~0.001);age(OR=1.062)and Hb A1C(OR=1.019)were positively correlated with the occurrence of prediabetes(P<0.05~0.01).Female(OR=0.062),DBP(OR=0.946),BMI(OR=0.861),Cr(OR=0.912),CTRP1(OR=0.912)are negatively correlated with the occurrence of prediabetes(P<0.05~0.001);Age(OR=1.062)and Hb A1C(OR=1.019)were positively correlated with the occurrence of prediabetes(P<0.05~0.01).CTRP1 is highly negatively correlated with whether blood lipids are abnormal(OR=0.990)(P<0.001);ALT(OR=1.010),GGT(OR=1.008),UA(OR=1.002)are positively correlated with whether blood lipids are abnormal(P<0.05~ 0.01).4.The diagnostic efficiency evaluation results show that CTRP1 uses 120.66 ng/ml as the best diagnostic cut-off point for T2 DM,the corresponding sensitivity and specificity are69.1% and 87.9%,respectively,and the area under the curve is 0.851;CTRP1 is 141.35ng/m The best diagnostic cut-off point for pre-diabetes,the corresponding sensitivity and specificity are 67.5% and 81.5%,respectively,and the area under the curve is 0.814;CTRP1 uses133.65ng/ml as the best diagnostic cut-off point for dyslipidemia,correspondingly The sensitivity and specificity were 42.4% and 71.9%,respectively,and the area under the curve was 0.582.Conclusion 1.CTRP1 in patients with abnormal glucose metabolism(type 2prediabetes,diabetes)showed low expression,and the serum CTRP1 level gradually decreased with the increase of fasting blood glucose,suggesting that CTRP1 may be a protective factor for glucose metabolism.2.CTRP1 is negatively correlated with HOMA-IR and positively correlated with HOMA-β,suggesting that insulin resistance increases significantly and the function of pancreatic β cells decreases with the increase of fasting blood glucose.CTRP1 may contribute to the secretory function of pancreatic β cells.3.CTRP1 in patients with abnormal glucose metabolism(pre-diabetes,diabetes)is negatively correlated with dyslipidemia,suggesting that CTRP1 reduction is closely related to dyslipidemia during the development of type 2 diabetes.4.CTRP1 has good sensitivity and specificity for the diagnosis of prediabetes and diabetic patients,suggesting that CTRP1 may be an important detection index for predicting the occurrence and development of type 2 diabetes.