Concomitant Clinical Symptoms In Children With Elevated ASO And The Effect Of Antibiotics/Immunoregulator Therapy On Its Titer

Objective:To investigate the clinical symptoms of children with elevated ASO and the probe of whether they need to be treated for a long-time.Methods: Total 529 children with ASO> 200IU/ml were included in this study.who were treated in the Department of Pediatric cardiology of Shengjing Hospital,China Medical University,from June 2012 to Jan 2021.All children treated with the first-generation cephalosporin or penicillin for 7-10 days at beginning,then ASO was retest.If ASO was still elevated,benzathine was administrated intramuscular,then discharged.Total 233 cases were followed up over one month.The clinical symptoms and ASO were compared.Those with repeat elevated ASO last for 3 months or with elevated ESR/CRP were administrated oral huaiqihuang for 3 months.The changes of ASO indexes and clinical symptoms were observed.Result:1.ASO titer decreased after intravenous treatment with different antibiotics,but there was no significant difference between groups,p >0.05.2.After intravenous antibiotics,the clinical symptoms mostly disappeared inner 2 months,showed significant difference,p<0.05.3.To those repeat elevated ASO last for 3 months,or with elevated ESR/CRP,huaiqihuang oral together with benzathine intramuscular injection can significantly accelerate ASO recovery,showed significant difference,p<0.05.Conclusion: Streptococcal infection is more happened in boys whose over than 5 years old.Intravenous antibiotic can significantly relieve the clinical symptoms of children with elevated ASO.Those only elevated ASO without ESR\CRP changes and clinical symptoms during the recovery period,follow-up alone does not require medicine intervention.For patients with repeated elevation of ASO or associated or with elevated ESR\CRP,huaiqihuang oral together with benzathine intramuscular injection can significantly accelerate the ASO recovery and reduce rebound.