Evaluation Of Left Ventricular Strain And Its Diagnostic Value In Dilated Cardiomyopathy By Cardiac Magnetic Resonance Feature Tracking Technology

Objective: To evaluate left cardiac function,left ventricular 3D strain and the diagnostic value of strain for non-ischemic dilated cardiomyopathy(NIDCM)in patients with NIDCM based on cardiovascular magnetic resonance feature tracking technology(CMRFT).Methods: Thirty-three patients(NIDCM group)and 33 healthy volunteers(control group)were enrolled in this study underwent cardiac MRI to compare the left ventricular function and strain parameters of the two groups.According to LGE results,the left ventricular myocardium in the NIDCM group was divided into LGE positive(164)and LGE negative(364)groups according to the 17-segment segmentation method,and the 3D strain parameters of the two groups were compared.Repeatability test,inter-group and intragroup mean comparison,Pearson correlation analysis,receiver operating characteristic(ROC)curve analysis were performed for each group.Results: The 3D global radial strain(GRS),global circumferential strain(GCS)and global longitudinal strain(GLS)in NIDCM group were lower than those in control group,the differences between the two groups were significant(P < 0.001).Left ventricular ejection fraction(LVEF)in NIDCM group was significantly lower than that in control group(P <0.001),left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV)and left ventricular mass(LVM)in the control group were higher than those in the control group(all P < 0.001).The LVEF in NIDCM group was negatively correlated with the GCS(P<0.01).There were significant differences in RS,CS and LS between LGE positive and LGE negative segments in NIDCM group(all P < 0.05).RS of LGE positive myocardial segments had certain diagnostic value in the diagnosis of NIDCM positive myocardial segments(AUC = 0.785),there was no significant diagnostic value for CS and LS(AUC = 0.584,0.665,respectively);Combined diagnosis showed RS+CS(AUC=0.789),RS+LS(AUC=0.811),CS+ LS(AUC=0.712),RS+CS+LS(AUC=0.810).Conclusion: Strain analysis using CMR-FT has good repeatability.LVEF in NIDCM group was strongly correlated with left ventricular GCS.Strain analysis using CMR-FT technology can identify myocardial fibrosis in patients with NIDCM without contrast agent and has potential clinical value.