Reasearch On Drug Resistance Of Enterococcus

Objective: To investigate the distribution and drug resistance of Enterococcus spp strains in Sheng Jing Hospital of China Medical University so as to provide reliable basis for clinical treatment.Methods: The Enterococcus spp strains were collected from our hospital during Jan1,2017 to Dec 31,2017.The clinical distribution characteristics and the drug resistance were analyzed retrospectively.Results:A total of 466 strain of Enterococcus were isolated,of which there were 211(45.28%)strains of Enterococcus faecium and 255(54.72%)strains of Enterococcus faecalis.The main source of Enterococcus spp strains were urine samples,followed by blood samples.The resistance rates of Enteococcus bacteria from urine samples were generally higher than the non-urine samples one.The department of pediatrics was the main distribution department of the E.faecium,while the department of urology was the most common department of E.faecalis.With the exception of tetracycline,rifampicin and quinopudine/dafopentin,E.faecium showed higher resistance to the rest 18 antibiotics than E.faecalis.But the resistance rate of E.faecium to quinopudine/dafopentin was 0,while the E.faecalis was 100%.Meanwhile,the resistance rate to clindamycin was 100%in both two types strains.No strains of tigecycline and linezolid resistance strain were found in this study.Conclusion: E.faecium was dominant among the Enterococcus spp,and the drug resistance rates were also significantly higher than the E.faecalis.The clinician should attach great attention to the emergence of glycopetide antibiotic resistant strains.Moreover,the monitoring of drug resisant strains should be further strengthened and the clinical application of common antibiotics should be standardized.