Cochlear Vibration Measurement Based On Swept Source Optical Coherence Tomography

Frequently swept source optical coherence tomography(SSOCT)has the characteristics of ultra-high speed scanning,non-invasive imaging,high resolution and real time imaging.It is widely used in clinical diagnostic fields such as corneal imaging,retinal imaging,Coronary atherosclerosis diagnosis and tumor diagnosis,etc.)has high application value.In this paper,based on the analysis and investigation of the domestic and foreign research on swept optical coherence tomography,it is applied to the mouse cochlea three-dimensional imaging and vibration imaging research,through theoretical analysis,simulation experiments and vibration imaging experiments to study the vibration measurement ability of swept OCT.The research of 3D imaging and vibration imaging of cochlea can better study the auditory nervous system and provide technical support for the field of brain science or the research of brain-computer interface.First,this paper analyzes the basic theory of vibration measurement of optical coherence tomography,and based on theory analysis to the frequency sweep optical coherence tomography and the mathematical model of vibration measurement,analyzes the cause of artifacts in the imaging process and method of remove artifacts,then analyses the key parameters in imaging system.Secondly,a simulation experiment is carried out on the basis of the established mathematical model.The influence of different optical power on the sensitivity of the system and the relationship between the axial resolution of the system and the bandwidth of the light source are simulated.The effect of removing the DC term under the condition of using balance detector is simulated.The simulation experiment is carried out based on the algorithm of removing artifacts to observe the effect of the algorithm.The noise in the imaging process is simulated and analyzed.The imaging effects of single and multilayer samples and the characteristics of Fourier transform images are studied.Finally,based on the results of theoretical and simulation experiments,the imaging scheme is designed and the range of parameter values is selected.The simple sample imaging experiments of single-layer mirror and multi-layer tape are carried out to further verify the imaging performance of the system.Finally,the vibration imaging experiment of the mouse cochlea stimulated by acoustic wave was carried out to analyze the sensitivity of the mouse cochlea to different sound frequencies.The validity and feasibility of the system for cochlea 3D imaging and vibration measurement are verified.